The invention discloses punching equipment for D500E alloy steel machining and relates to the technical field of alloy steel machining. The equipment comprises a frame, a control panel, a ground foot,an operation panel and a stand column, wherein the control panel is embedded and mounted on the front side of the frame, the ground foot is fixedly mounted on the lower surface of the frame, the operation panel is fixedly mounted on the top end of the frame, and the stand column is fixedly mounted on the position, located on one side of the operation panel, of the top end of the frame. The equipment is scientific and reasonable in structure and convenient to operate, fixing work for machining alloy steel can be achieved through a clamping mechanism and a driving mechanism which are arranged,convenience is provided for punching operation, practicability is increased, the equipment can be suitable for fixing workpieces with different sizes, the use range of the equipment is enlarged, leftand right sliding of a sliding plate can be achieved through an arranged sliding mechanism, and therefore left and right sliding of a drill bit can be achieved. The automation degree and the safety are improved, and the working efficiency is effectively improved.