The invention discloses an automatic tooling replacement device which comprises a fixed base, a tooling support and a fast replacement device, wherein the fixed base is mounted on the ground, the tooling support is arranged on the fixed base, the fast replacement device is loaded at the top end of the tooling support, the fixed base is provided with a double-acting structure, the double-acting structure is provided with a cylinder for driving a chain wheel and a chain and drives the tooling support to rapidly enter and exit, the tooling support is provided with double positions, the fast replacement device comprises a second cylinder and an automatic fast replacement disk, and the second cylinder drives the automatic fast replacement disk to automatically lock and unlock. According to the automatic tooling replacement device, by the aid of a double-acting translation mode of the chain wheel and the chain driven by the cylinder and the fast replacement device, a tooling can be automatically replaced by programming, manual operation is omitted, and the automatic tooling replacement device is innovative. The automatic tooling replacement device is compact in integral structure, small in occupied space, easy to maintain and cannot be limited by sound insulation protection of a whole press line, replacement time of the tooling is short, replacement efficiency of the tooling is high, and economic benefits of enterprises can be improved.