The invention relates to a curve simulation S-shaped wedge block compensation device. The curve simulation S-shaped wedge block compensation device comprises a compensation groove platform, a plurality of upper S-shaped wedge blocks, an integral lower S-shaped wedge block, a bottom plate, adjusting screws and a transmission mechanism, wherein the upper S-shaped wedge block and the integral lower S-shaped wedge block are placed in a groove in the bottom of the compensation groove platform in a matched mode, the bottom plate is fixedly connected with the compensation groove platform through bolts, and the adjusting screws penetrate through the compensation groove platform and are connected with nuts embedded in the upper S-shaped wedge blocks. The transmission mechanism comprises a first lead screw, a second lead screw, a connecting block, a motor and a speed reducer, the motor and the speed reducer are fixedly installed at one end of the compensation groove platform through a first connecting block, the right end of the first lead screw is connected with the speed reducer, an internal thread at the left end of the first lead screw is connected with an external thread at the right end of the second lead screw, and the left end of the second lead screw is connected with the lower S-shaped wedge block through the connecting block. By means of compensation for deformation of a machine tool, the curve simulation S-shaped wedge block compensation device can improve accuracy of the angle and the straightness of a bent workpiece, and guarantees product quality of the bent workpiece.