The invention discloses a self-alignment preparation method for a self-alignment gate-drain negative overlapping region of a tunneling field effect transistor, and belongs to the field of field effecttransistor logic devices and circuits in a CMOS ultra-large integrated circuit (ULSI). According to the method, asymmetric side wall structures are designed on the two sides of a tunneling transistorgate, the side, close to a source end, of the gate is a thin side wall, and the side, close to a drain end, of the gate is a thick side wall. According to the invention, by reasonably utilizing the thin side wall and the thick side wall in the standard CMOS process, the thin side wall at the source end is used as a hard mask for transistor source region injection, and the thick side wall at the drain end is used as a hard mask for transistor drain region injection, so that special materials and special processes are not introduced, the bipolar effect of a tunneling field effect transistor (TFET) is inhibited, the fluctuation characteristic of the device is optimized, it can be guaranteed that the TFET can be mixed and integrated with a standard CMOS device, and complex and diversified circuit functions are achieved.