42 results about "Binding pattern" patented technology

A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.

A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.

The embodiment of the invention provides a touch substrate and a manufacturing method thereof and a touch device, and relates to the technical field of touch. Signal lines which are connected with touch electrodes which are transversely and longitudinally arranged in a crossed manner are arranged on different layers, so that the width of a routing region can be reduced. The touch substrate comprises a plurality of transversely and longitudinally crossed first touch electrodes and second touch electrodes arranged on a substrate in a touch area, a plurality of first binding patterns and a plurality of second binding patterns arranged at one side of the touch area, first signal lines connected with the first touch electrodes and the first binding patterns, and second signal lines connected with the second touch electrodes and the second binding patterns; the first signal lines and the second signal lines are arranged on different layers; and the projection of the area in which the first signal lines are located on the substrate and the projection of the area in which the second signals are located on the substrate have one part of overlapping area.

The present invention describes a method for the rapid binding of pathogenic microorganisms and their toxic proteins with ligands that have been covalently tethered at some distance from the surface of a substrate. Ligands directed to microbes are covalently attached to the substrate surface by tethers that are between 35 Å and 50 Å in length for optimal binding efficacy. Ligands directed to capture and concentrate proteinaceous materials are covalently attached to the substrate surface by tethers that are between 35 Å and 50 Å in length for optimum assay kinetics. The ligands described herein include heme compounds, siderophores, polysaccharides, and peptides specific for toxic proteins, outer membrane proteins and conjugated lipids. Non-binding components of the solution to be analyzed are separated from the bound fraction and binding is confirmed by detection of the analyte via microscopy, fluorescence, epifluorescence, luminescence, phosphorescence, radioactivity, or optical absorbance. By patterning numerous ligands in an array on a substrate surface it is possible to taxonomically identify the microorganism by analysis of the binding pattern of the sample to the array.

The present invention provides a lithographic difficulty metric that is a function of an energy ratio factor that includes a ratio of hard-to-print energy to easy-to-print energy of the diffraction orders along an angular coordinate θi spatial frequency space, an energy entropy factor comprising energy entropy of said diffraction orders along said angular coordinate θi, a phase entropy factor comprising phase entropy of said diffraction orders along said angular coordinate θi, and a total energy entropy factor comprising total energy entropy of said diffraction orders. The hard-to-print energy includes energy of the diffraction orders at values of the normalized radial coordinates r of spatial frequency space in a neighborhood of r=0 and in a neighborhood of r=1, and the easy-to-print energy includes energy of the diffraction orders located at intermediate values of normalized radial coordinates r between the neighborhood of r=0 and the neighborhood of r=1. The value of the lithographic difficulty metric may be used to identify patterns in a design layout that are binding patterns in an optimization computation. The lithographic difficulty metric may be used to design integrated circuits that have good, relatively easy-to-print characteristics.

The present invention provides a method for globally mapping a genome for its protein-binding pattern. A computer system useful for this purpose is also described.

The invention discloses a display panel, a manufacturing method thereof and a display device, and belongs to the technical field of display. The method comprises the steps: forming a binding pattern comprising at least one conducting layer on a substrate, wherein the surface, away from the substrate, of each conducting layer has a binding area; forming a flat layer on the substrate on which the binding pattern is formed, and processing the flat layer into a flat layer pattern, wherein the flat layer pattern comprises an opening area and a shielding area, the orthographic projection of the binding area on the substrate being located in the orthographic projection of the opening area on the substrate, and the orthographic projection of the side surface of the conducting layer on the substrate being located in the orthographic projection of the shielding area on the substrate. In this way, the shielding area can cover the area, where an interlayer is possibly exposed, of the side surfaceof the conducting layer, so that replacement reaction between anode etching liquid and metal material of the interlayer is avoided, the risk of short circuit caused by the fact that replaced metal isattached to the binding pattern is also avoided, and the abnormal display phenomenon of the display panel is also avoided.

The invention provides a panel and a display device provided with the panel. The panel comprises a first transparent substrate, a first conducting layer positioned at the outer side of the first surface of the first substrate, and a second conducting layer positioned at the outer side of the second surface of the first substrate, wherein the first conducting layer comprises a binding area which is provided with a plurality of binding patterns, the second conducting layer comprises a plurality of opaque wires, engraved seams exist between adjacent opaque wires, the second conducting layer is provided with a projecting region in the binding region, the projecting region also comprises a plurality of sub projecting regions, and light transmitting through the engraved seams of the opaque wires of the second conducting layer is enabled to be clear enough for a user to observe the binding condition of the binding patterns through controlling the proportion X of the light transmitting area in the at least one sub projecting region to the area of the sub projecting regions.

Reagents, methods, and kits for the classification of cancer that comprise or employ antibodies that bind specific regions of CD43. One method includes contacting tissue with an antibody capable of specifically binding the cytoplasmic tail of CD43, contacting the tissue with an antibody capable of specifically binding the extracellular domain of CD43, and resolving cellular localization of any binding to the tissue with the antibody capable of specifically binding the cytoplasmic tail of CD43 and the antibody capable of specifically binding the extracellular domain of CD43. The binding patterns of the antibodies can be used to characterize cancer as more aggressive or less aggressive and can distinguish small cell lung cancer from non-small cell lung cancer. The cancer may therefore be treated in accordance of the characterization.

A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.

A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.

A method of evaluating for the presence of a target polynucleotide in a sample, using an addressable array of multiple polynucleotide probes linked to a substrate. The sample is exposed to the array and a set of polynucleotide target probes, such that target polynucleotide which may be present will bind to a predetermined feature of the array through multiple target probes of the set by forming at respective target regions on a target molecule, simultaneous hybrids with anti-target regions of the multiple target probes. A binding pattern on the array is observed and the presence of the target polynucleotide evaluated based on the observed binding pattern. Kits using such arrays, and methods for selecting target probes are further provided.

The invention provides a sign language recognition method based on a deep belief network (DBN) and multi-mode characteristics, and relates to the field of image processing technology and machine learning. The method comprises the following steps of: obtaining a sample; inputting a sign language image or video; preprocessing the sign language image; extracting a Histogram of direction gradient histogram (HOG); Characteristics such as local binary patterns (Local Binding Patterns, LBP) and Zernike moments are used as characteristic parameters, and a deep belief network is used for training and identification. The method can identify sign language information in the image in real time, and has high identification accuracy.

The invention provides a compound which competitively inhibits the binding of a norovirus with a native blood antigen of a human host, as well as a kit for determining whether an individual has been infected by a norovirus. Also provided is a method for determining the susceptibility of an individual to infection by a particular, known strain of norovirus. The invention is based on the determination that noroviruses recognize human blood antigens such as human histo-blood group antigens (HBGAs) as a receptor in seven specific binding patterns. The invention allows one to predict that a particular strain of norovirus can infect humans who have a particular human histo-blood type, as well as blood antigens that can bind the particular strain of infecting norovirus. The invention also allows one to predict that a particular strain of norovirus will bind with one or more particular histo-blood group antigens, but will not bind with other blood group antigens.

Gold-like porcelain as special ornaments is products by: making formworks, binding patterned stainless steel or brass wires onto them, enameling with pigments, firing in a common furnace at 550-700 deg.C for 20-30 minutes, cooling ni a thermal keeping furnace to the amtosphere, and polishing the patterned wires. It is a metal-porcelain combined handicraft in small sizes or a large picture on wall with lively appearance and stereo visual feeling.

The invention provides a compound which competitively inhibits the binding of a norovirus with a native blood antigen of a human host, as well as a kit for determining whether an individual has been infected by a norovirus. Also provided is a method for determining the susceptibility of an individual to infection by a particular, known strain of norovirus. The invention is based on the determination that noroviruses recognize human blood antigens such as human histo-blood group antigens (HBGAs) as a receptor in seven specific binding patterns. The invention allows one to predict that a particular strain of norovirus can infect humans who have a particular human histo-blood type, as well as blood antigens that can bind the particular strain of infecting norovirus. The invention also allows one to predict that a particular strain of norovirus will bind with one or more particular histo-blood group antigens, but will not bind with other blood group antigens.

The present invention provides a lithographic difficulty metric that is a function of an energy ratio factor that includes a ratio of hard-to-print energy to easy-to-print energy of the diffraction orders along an angular coordinate θi of spatial frequency space, an energy entropy factor comprising energy entropy of said diffraction orders along said angular coordinate θi, a phase entropy factor comprising phase entropy of said diffraction orders along said angular coordinate θi, and a total energy entropy factor comprising total energy entropy of said diffraction orders. The hard-to-print energy includes energy of the diffraction orders at values of the normalized radial coordinates r of spatial frequency space in a neighborhood of r=0 and in a neighborhood of r=1, and the easy-to-print energy includes energy of the diffraction orders located at intermediate values of normalized radial coordinates r between the neighborhood of r=0 and the neighborhood of r=1. The value of the lithographic difficulty metric may be used to identify patterns in a design layout that are binding patterns in an optimization computation. The lithographic difficulty metric may be used to design integrated circuits that have good, relatively easy-to-print characteristics.

The invention provides an intermediate number management control method and an intermediate number management control device, which relate to the technical field of communication. The intermediate number control method comprises the following steps: determining a required binding mode based on the received binding request information; obtaining an intermediate number in the number pool, and judging whether the intermediate number can establish a binding relationship based on the determined binding mode and the telephone number corresponding to the binding request information; If the intermediate number can establish binding relationship with the telephone number corresponding to the binding request information based on the determined binding mode, establishing binding relationship betweenthe intermediate number and the telephone number corresponding to the binding request information according to the determined binding mode. By using the above method, the problem of unstable bindingrelationship existing in the existing intermediate number technology can be improved.

The invention provides a fiber composite material rib connecting piece. The fiber composite material rib connecting piece includes a tube-shaped sleeve, bolts and two umbrella-type anchor devices; thetube-shaped sleeve includes an upper sleeve and a lower sleeve; the upper sleeve is fixedly connected with the lower sleeve; the umbrella-type anchor devices include anchorage devices, sliding blocks, anchor rods and supporting rods; two anchor devices are separately and fixedly connected at the connecting ends of two to-be-connected fiber composite material ribs; one ends of the anchor rods arerotatably connected with the anchorage devices and the other ends of the anchor rods abut against locking blocks; one ends of the supporting rods are slidably connected with the anchor rods and the other ends of the supporting rods are rotatably connected with the sliding blocks; and the fiber composite material rib is sleeved with the sliding blocks which are fixedly connected with the pipe wallof the tube-shaped sleeve. According to the fiber composite material rib connecting piece, while a longitudinal connection between the fiber composite material ribs is completed, the problem that ironwires are corroded to generate failure of the fixed connection between the fiber composite material ribs can be avoided and meanwhile the problem that the damage of the surface structures of the fiber composite material ribs happens due to binding patterns can be avoided, and the performance and the service life of the fiber composite material ribs are improved.

A fabric belt for producing a web material, the fabric belt including a first layer on a web material side and a second layer on a machine side of the belt. The layers each having a basic weave connected to each other by binding threads extending in a binding thread direction. The layers having base binding threads extending both in and transverse to the binding thread direction. The binding threads form binding segments which are successive in the binding thread direction in the second layer. The binding threads are tied off on one base binding thread of the second layer extending transversely to the binding thread direction. The binding segments formed in the second layer are arranged in a binding pattern repeat extended in and transverse to the binding thread direction along a binding segment diagonal progressing obliquely to the binding thread direction and transverse to the binding thread direction.

A brushless motor includes a stator as an armature where a plurality of coils is housed and a rotor as a magnetic exciter having a permanent magnet, wherein an end portion of the coil housed in a slot of a stator stack is inserted into a wire binding board having a wire binding pattern of the coil, the end portion of the coil is soldered to a land of the wire binding board, and the wire binding board and a circuit board are electrically conducted to each other through an connecting terminal.

The invention discloses an anti-dazzle circular daily ceramic device applique out-of-bound detection method. The method comprises the steps of: first, obtaining a dazzle-free original ceramic grayscale image in the low-light condition through a camera; second, obtaining a grayscale enhanced image which is apparent in contrast; third, obtaining a binary image through a threshold segmentation technology; fourth, filling the outermost boundary inner area; fifth, obtaining a second outer boundary with probable out-of-bound patterns through an image residual error technology; sixth, filling the inner area of the second outer boundary and obtaining the contour of the second outer boundary through a boundary extraction operator; seventh, determining the center of the circular ceramic device and drawing a radius curve, a radius residual error curve and a radius residual error power exponent curve; eighth, positioning the out-of-bond patterns and measuring the dimension. The method is efficient and convenient, simple and convenient to operate and provided with broad market prospects.

A method for binding pattern in reinforced photo-etching process includes carrying out several times of plasma alkaline treatments on film before photo-etching process is done, forming cross-linked projection unit at bottom of photosensitive-material pattern then using dry-etching means to remove off said cross-linked projection unit of bottom film.

A new approach to identifying binding conformations of chemical fragments and biological molecules is presented, in which fragment poses are explored in a systematic fashion. In an embodiment, for each pose, a fast computation is performed of the fragment interaction with the biological molecule using interpolation on a grid. Once the energies of fragment poses are computed, thermodynamical quantities such as binding affinity, binding enthalpy, and binding entropy are computed by direct sum over fragment poses. Using the present invention, it is possible to navigate fragment configuration space to identify separate binding modes. The present invention can be used to scan an entire biological molecule to identify possible binding pockets, or it can be used for localized explorations limited to interesting areas of known binding pockets.

The present invention provides a lithographic difficulty metric that is a function of an energy ratio factor that includes a ratio of hard-to-print energy to easy-to-print energy of the diffraction orders along an angular coordinate [theta]i of spatial frequency space, an energy entropy factor comprising energy entropy of said diffraction orders along said angular coordinate [theta]i, a phase entropy factor comprising phase entropy of said diffraction orders along said angular coordinate 6,, and a total energy entropy factor comprising total energy entropy of said diffraction orders (430, 440).; The hard-to-print energy includes energy of the diffraction orders at values of the normalized radial coordinates r of spatial frequency space in a neighborhood of r=0 and in a neighborhood of r=l, and the easy-to-print energy includes energy of the diffraction orders located at intermediate values of normalized radial coordinates r between the neighborhood of r=0 and the neighborhood of r=l. The value of the lithographic difficulty metric may be used to identify patterns in a design layout that are binding patterns in an optimization computation. The lithographic difficulty metric may be used to design integrated circuits that have good, relatively easy-to-print characteristics.

A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.

The present invention relates to a method for analyzing the pattern of live intercellular membrane protein binding. The method for analyzing the pattern according to the present invention can analyze accurately, sensitively, quickly, and readily the binding pattern of a target membrane protein and a candidate substance to be specifically bound therewith without tagging to a ligand, and thus measure directly and accurately the position and quantitative information of the binding of the membrane protein and the target substance. Such effects make it possible to apply the method for various uses such as dissociation constant, mutant study, complex formation, and signal transduction. Moreover, it is expected to use the method for searching out undiscovered membrane proteins and target substances.

A method of evaluating for the presence of a target polynucleotide in a sample, using an addressable array of multiple polynucleotide probes linked to a substrate. The sample is exposed to the array and a set of polynucleotide target probes, such that target polynucleotide which may be present will bind to a predetermined feature of the array through multiple target probes of the set by forming at respective target regions on a target molecule, simultaneous hybrids with anti-target regions of the multiple target probes. A binding pattern on the array is observed and the presence of the target polynucleotide evaluated based on the observed binding pattern. Kits using such arrays, and methods for selecting target probes are further provided.

The purpose of this invention is to stabilize the binding pattern of a pair of binding bands, when a wire harness fixture is secured while binding a wire harness with the pair of binding bands.The wire harness fixture (50) is secured to a wire harness (WH) with a pair of binding bands (60) bound to the wire harness (WH). The wire harness fixture includes a fixing body part (52) capable of being fixed to an object to which the wire harness (WH) is to be secured and a band insertion part (58) having a pair of band insertion holes (58a) in which the pair of binding bands (60) can be inserted separately from each other in substantially parallel state.

A new approach to identifying binding conformations of chemical fragments and biological molecules is presented, in which fragment poses are explored in a systematic fashion. In an embodiment, for each pose, a fast computation is performed of the fragment interaction with the biological molecule using interpolation on a grid. Once the energies of fragment poses are computed, thermodynamical quantities such as binding affinity, binding enthalpy, and binding entropy are computed by direct sum over fragment poses. Using the present invention, it is possible to navigate fragment configuration space to identify separate binding modes. The present invention can be used to scan an entire biological molecule to identify possible binding pockets, or it can be used for localized explorations limited to interesting areas of known binding pockets.