23 results about "Cornea thickness" patented technology

The invention relates to a method for providing control data for an ophthalmic laser (12) of a treatment device (10).The procedure comprises the following steps: determining a preoperative corneal thickness profile (24) of a cornea (16) of a human or animal eye from predetermined examination data; determining a target corneal thickness profile (26) of the cornea (16), wherein at least one corneal thickness of the target corneal thickness profile (26) is set to a predetermined corneal thickness value (28) present at at least one predetermined position of the preoperative corneal thickness profile (24); determining tissue removal data to generate the target corneal thickness profile (26), wherein in the tissue removal data only tissue (14) at positions between the preoperative corneal thickness profile (24) and the target corneal thickness profile (26) is defined as tissue (14) to be removed; and providing control data for controlling the ophthalmic laser (12), which includes the tissue removal data.

The invention discloses a corneal endothelial cell meter light path system and a corneal endothelial cell meter, and relates to the technical field of ophthalmology medical equipment.The corneal endothelial cell meter light path system comprises a first optical branch, a first auxiliary branch, a second optical branch and a second auxiliary branch; the first optical branch is used for corneal endothelial cell imaging; the first auxiliary branch and the first optical branch are symmetrically arranged, and the first auxiliary branch is used for providing a light source when the first optical branch is used for corneal endothelial cell imaging; the second optical branch is used for measuring the cornea thickness; and the second auxiliary branch is used for assisting the second optical branch in measuring the cornea thickness and positioning the Z axis of the human eye. According to the technical scheme, the optical path system of the corneal endothelial cell meter can be used for imaging the cornea and measuring the thickness of the cornea through optical path arrangement of the first optical branch, the first auxiliary branch, the second optical branch and the second auxiliary branch, the cornea and the thickness of the cornea do not interfere with each other and can be measured at the same time, and the optical path system is low in installation and adjustment difficulty and easy to develop.

The present invention discloses an intraocular irrigation solution containing niacinamide. Niacinamide serves as an active substance in the intraocular irrigation solution, which has the effects of improving the function of corneal endothelial cells, inhibiting cell apoptosis and cell fusion, and improving the mitochondrial damage condition, thereby alleviating or inhibiting corneal edema, reduction of corneal endothelial cells, abnormal corneal transparency, abnormal corneal thickness, abnormal corneal endothelial cell density, abnormal corneal endothelial cell morphology, and abnormal expression of corneal endothelial cell functional proteins caused by ultrasonic stimulation, heat stimulation or oxidative damage to corneal endothelial cells during phacoemulsification surgery.

Disclosed is a method of measuring an eye property value. The method comprises a. analyzing a spectrum of light intensity (214, 306) received by illuminating an eye (210) with a confocal chromatic sensor (202), b. identifying a first peak (302) and a second peak (304) from the measured spectrum of light intensity, wherein the first peak is associated with an anterior surface (206) of a cornea (208) and the second peak is associated with a posterior surface (212) of the cornea, c. calculating a thickness of the cornea based on a difference between the first peak and the second peak, d. repeating steps a – c to determine a change of the thickness as a function of time.

Systems and methods for determining IRA candidacy and optimizing autologous corneal graft location and orientation to standardize and improve IRA procedures. A novel digital virtual model (i.e., a digital twin) of the eye is provided that integrates corneal imaging, pachymetry, topography and limbus / white-to-white measurements, and automates key surgical variables such as trephine size, autologous corneal graft rotations, and curvature and thickness matching, reducing cognitive load on the surgeon and improving accuracy. The embodiments herein provide precise graft placement parameters to maximize the amount of clear cornea in the visual axis. By providing real-time, patient specific guidance, the present embodiments enhance surgical precision and visual outcomes.

This application discloses a method for detecting corneal thickness after phacoemulsification cataract surgery based on anterior segment OCT, belonging to the field of image analysis technology. The method includes: dividing the cornea into multiple first regions based on a region growing algorithm and initial corneal thickness data; obtaining second regions based on each first region; obtaining multiple partial boundaries based on the second regions; obtaining fibrotic regions based on each partial boundary; and adjusting the scanning density and refractive index of the second regions based on the fibrotic regions and a scanning density correction coefficient to obtain the final corneal thickness data. This application combines the fibrotic regions and the scanning density correction coefficient to adjust the scanning density and refractive index of the second regions, avoiding the errors of calculations using a uniform refractive index in existing technologies, ultimately achieving accurate measurement of corneal thickness and solving the technical problem that existing OCT detection cannot accurately measure corneal regional thickness.

The invention discloses a cataract ultrasonic emulsification postoperative cornea thickness detection method based on anterior segment OCT, and relates to the technical field of image analysis. The method comprises the following steps: dividing a cornea into a plurality of first regions based on a region growing algorithm and initial cornea thickness data; acquiring a second area based on each first area; acquiring a plurality of partial boundaries based on the second region; based on the boundaries of all the parts, a fibrosis area is obtained; and adjusting the scanning density and the refractive index of the second region based on the fibrosis region and the scanning density correction coefficient to finally obtain cornea thickness data. According to the method, the scanning density and the refractive index of the second area are adjusted by combining the fibrosis area and the scanning density correction coefficient, so that the error of calculation by using a unified refractive index in the prior art is avoided, accurate measurement of the cornea thickness is finally realized, and the technical problem that the thickness of the cornea area cannot be accurately measured through existing OCT detection is solved.

The invention discloses a cornea thickness meter and a cornea thickness measuring method, and relates to the technical field of cornea thickness meters, the cornea thickness meter comprises a lower base, an upper base, a thickness meter, a face limiting frame, a transverse adjusting assembly and a face adjusting assembly; an optical transmitting module, an optical receiving module, an ultrasonic auxiliary module and a data processing module are arranged in the thickness meter, a physical positioning mark is formed through high-frequency ultrasonic waves to determine an optical measurement area, and cornea stimulation and measurement deviation are avoided; the transverse and face adjusting assemblies are matched with a distance sensor to achieve automatic and accurate adjustment of the head position of a tester, and in addition, the data processing module is combined with wavelet filtering, an FFT algorithm and a curvature correction formula to achieve real-time processing of multi-channel signals and accurate calculation of the thickness; the problems of measurement deviation and data processing delay caused by low manual adjustment precision and irregular cornea surface of a traditional thickness gauge are effectively solved, and the cornea thickness gauge has the advantages of operation convenience, measurement accuracy and data management convenience.

The present invention provides a non-contact tonometer measurement method and a non-contact tonometer. The non-contact tonometer measurement method includes the following steps: obtaining a first human eye image in the XY direction and a second human eye image in the Z direction of a subject's eye; identifying the first human eye image according to a pupil recognition method and a positioning light point detection method to determine the centroid of the pupil and pupil contour of the subject's eye; identifying the corneal bright line in the second human eye image according to a corneal bright line detection method to determine the corneal vertex of the subject's eye; performing XY direction positioning adjustment based on the centroid of the pupil and pupil contour, and performing Z direction positioning adjustment based on the corneal vertex and a calibration point in the Z direction; in response to completion of the XY direction positioning adjustment and the Z direction positioning adjustment, blowing air into the subject's eye to obtain a corneal deformation image captured by a high-speed camera sensor; and determining the intraocular pressure value of the subject's eye based on the corneal thickness and corneal curvature determined from the corneal deformation image and the pressure change curve of the blowing air chamber.

1. The name of the design product: frequency domain biometry. 2. The use of the design product: for measuring biological parameters of the eye, such as measuring axial length, central corneal thickness, corneal curvature, anterior chamber depth, pupil diameter, white-to-white distance, corneal astigmatism axis, lens thickness, retinal thickness, choroidal thickness, and calculating the power of the artificial lens to be implanted. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention provides a personalized eyeball model establishment method suitable for finite element simulation, and relates to the technical field of finite element simulation, and the method specifically comprises the steps: importing an eye OCT image into three-dimensional modeling software, and obtaining structural information; an ellipse is drawn based on the information, the long axis is the length of the equatorial part of the eyeball, and the short axis is twice the distance from the equatorial part to the posterior pole; a quarter of the upper right portion of the cut ellipse is reserved, and the cut ellipse is offset outwards by 1 mm to form an equatorial posterior sclera outline; drawing an eye axis straight line and a cornea thickness straight line, zooming and moving the OCT image to enable the OCT image to coincide with the cornea thickness straight line; drawing a cornea contour and a trabecular mesh contour according to the OCT image, and forming sclera vein sinus after biasing; and symmetrically drawing to obtain a complete section, and rotating by 360 degrees to generate a three-dimensional eyeball model. The method is based on common ophthalmic examination data, is easy to obtain, has high accuracy, can significantly improve the authenticity and precision of the model, and improves the prediction accuracy of ophthalmic diagnosis and treatment.

The present invention belongs to the technical field of drug preparation and relates to a nicotinamide-containing intraocular surgical irrigation solution and its preparation and application. The present invention provides the use of nicotinamide in an intraocular surgical irrigation solution. The present invention uses nicotinamide to improve the intraocular surgical irrigation solution, which can inhibit corneal endothelial cell damage caused by cataract phacoemulsification surgery, reduce corneal edema caused by cataract phacoemulsification surgery, avoid a significant decrease in the number of corneal endothelial cells caused by surgery, promote the recovery of corneal transparency after surgery, promote the recovery of normal corneal thickness, maintain the normal density, cell morphology, and regular expression of functional proteins of corneal endothelial cells, and reduce complications caused by cataract phacoemulsification surgery. The present invention can provide an effective strategy for the rapid recovery of normal visual function in cataract patients after surgery.

The present invention relates to a composition for preventing or treating ocular diseases, comprising Aloe vera gel. Specifically, when orally administered, the Aloe vera (A.vera) gel has been confirmed to have an excellent effect of increasing the expression of genes related to the improvement of tear volume, corneal non-uniformity, eye inflammation, dry eye, corneal thickness, and tear film. Accordingly, the Aloe vera gel can be advantageously used as an active ingredient in an oral composition for the prevention, alleviation, or treatment of ocular diseases, including dry eye syndrome.

The present disclosure relates to a method of measuring a thickness (d2) of a cornea (114). The method comprises: measuring a distance (d1) between a pachymeter (100) and an outer surface (162) of the cornea using a confocal chromatic sensor (102), when a light intensity (302) of a light source (104) of the confocal chromatic sensor is set at a first value (V1); comparing the measured distance with a predetermined distance range; and if the measured distance is in the predetermined distance, measuring the thickness of the cornea with the confocal chromatic sensor, wherein the light intensity of the light source of the confocal chromatic sensor is set at a second value (V2). The present disclosure further includes a pachymeter (100) for measuring the thickness of the cornea.

A high-resolution handheld OCT imaging system related to the optical imaging field solves the issues of handheld OCT systems with low resolution and the inability to measure the skin's stratum corneum thickness accurately. Through adopting the visible wavelength band of supercontinuum laser as the light source, mainly applying reflectors instead of lenses in the OCT system, and replacing fiber propagation with optical propagation in free space in the interference optical paths, to significantly reduce dispersion loss in the axial resolution and improve the axial resolution of OCT systems. The filter, attenuator, grating, camera, and other components are separated from the handheld module through modular design to reduce the handheld terminal's size and weight and realize the system construction. The invention improves the axial resolution, obtains the thickness information of whole-body skin's stratum corneum, and provides technical approaches for skin diagnosis and related medicine development.

Method for providing control data for an ophthalmic surgical laser, wherein the method comprises the following steps performed by a control device (20): - Determining refractive error data describing a degree of refractive error of a human or animal eye (40) (S1), - Determining an actual geometry of a correction area (32) of a cornea (17) of the eye (40), which describes three-dimensional dimensions of the correction area (32) of the cornea (17) (S2), - based on the determined refractive error data and the determined actual geometry: Determining a target geometry of the correction area (32) that describes a reduction component (44) of the correction area (32) with a corneal thickness reduced compared to the actual geometry, and / or a thickening component (42) with a corneal thickness increased compared to the actual geometry; wherein the determined target geometry fulfills a predefined refractive error reduction criterion that specifies suitability for reducing the degree of refractive error (S3), - Specifying the angle of rotation and the axis of rotation (31) depending on: a) a result of a comparison of the determined actual geometry with the determined target geometry, and / or b) the determined visual impairment data (S5), - based on the determined actual geometry: Determining interfaces (14, 16) of a lenticel (12) within the correction area (32), which extends at least partially over the correction area (32), wherein a portion of the lenticel (12) is designed such that, when the lenticel (12) is rotated (D) into the thickening portion (42) about the specified axis of rotation (31) passing through the cornea (17) and about the specified angle of rotation, it transforms the correction area (32) from the determined actual geometry into the determined target geometry (S4), - Defining at least one incision path as access for an instrument to rotate the lenticule (12), which extends from a predetermined incision site on an outer surface of the cornea (17) to one of the defined interfaces (14, 16) (S7), and - Providing control data that describe the determined interfaces (14, 16) for forming the lenticel (12), the at least one determined incision path, the specified axis of rotation (31) and a rotation of the lenticel (12) about the specified angle of rotation (S6).

According to the intraocular pressure measuring method and device, the hardware structure is simplified through the steady-state measuring principle, the complexity of real-time eyeball tracking and multi-joint position adjustment is avoided, therefore, the system error and maintenance requirements are reduced, and the measuring stability and clinical applicability are improved; by measuring the response characteristics of the cornea under the steady-state pressure and adding a compensation coefficient corresponding to different cornea thicknesses, cornea differences of different individuals are effectively adapted, the measurement precision and reliability are ensured, and meanwhile, the cornea measuring device has the multiple advantages of being simplified in structure, low in cost, convenient to clinically popularize and the like. And an innovative technical solution is provided for non-contact intraocular pressure measurement.

The invention relates to an eye biological characteristic measurement method and system, an intelligent terminal and a storage medium, and relates to the technical field of eye vision optics, and the method comprises the steps: responding to a measurement signal, and starting an air pressure control module in a measurement instrument according to a first air pressure working mode; turning on a first annular light source and a projection light source; receiving the first light beam reflected by the cornea to obtain a first circular ring virtual image; calculating a first cornea curvature radius according to the radius of the first circular ring virtual image; receiving the second light beam reflected by the cornea to obtain a front surface imaging point and a rear surface imaging point; obtaining the cornea thickness according to the positions of the front surface imaging point and the rear surface imaging point; starting an air pressure control module according to a second air pressure working mode; acquiring a second cornea curvature radius; calculating to obtain initial intraocular pressure; and outputting the first cornea curvature radius, the cornea thickness and the initial intraocular pressure as eye biological characteristics to a display screen of the measuring instrument. The method has the effect of improving the measurement efficiency of the eye biological characteristics.

The present invention relates to an instrument and method comprising a system for projecting structured light in the form of points onto a specific area, such as the cornea of ​​the eye. It also includes an observation system for capturing and recording images on a computer, as well as a method that uses computational algorithms to triangulate the information and derive corneal topography and pachymetry, including conjunctival-scleral topography, from a single image without the need for scanning. The results of the method for determining the topography and pachymetry are displayed on a monitor. Furthermore, it uses fewer optical elements and does not require a stereoscopic system for triangulation, making it more cost-effective compared to commercial clinical instruments that require scanning to cover the entire cornea by projecting a flat beam of light obtained from a slit lamp.Furthermore, obtaining corneal information is simplified with a single image, and the results are useful for optometrists and ophthalmologists, as well as the ophthalmic industry, because in addition to the eye, it can also be applied to a variety of lenses.

The invention relates to a system, a method, and a functional element wearable on the user's head for obtaining ophthalmic diagnostic information, in particular for measuring intraocular pressure in an eye. The thickness of the cornea and / or the anterior chamber volume of the eye are determined by means of electromagnetic radiation.

To provide illumination and imaging techniques to determine a corneal thickness.SOLUTION: In a corneal measurement system, an optical element 112 focuses an excitation light on an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to a cornea 2 generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller 120 receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.SELECTED DRAWING: Figure 1

The application relates to the field of biomedical engineering and particularly discloses hollow virus-like nanoparticles for corneal crosslinking as well as a preparation method and application thereof. In view of problems such as the need to destroy epithelium in traditional crosslinking, ultraviolet toxicity and insufficient penetration of sonodynamic carriers, the following scheme is adopted: ① a CTAB / NaOH micelle is used as a template, a TEOS cyclohexane solution is self-assembled to form virus-like silica particles, a hollow ruthenium-based carrier is obtained through RuCl3 deposition and Na2CO3 etching, and a Ru-TiO2 heterojunction mesoporous shell is formed by coating tetrabutyl titanate; ② the nanoparticles are dispersed into a 0.5-5 mu g / mL suspension and instilled on an eye surface, and 1.0-1.5 MHz, 2-3 W / cm2 pulse ultrasound (duty ratio 50-70%, 10-20 min) is applied. The advantage lies in that the virus-like spike structure realizes non-invasive penetration (fluorescence intensity 106.5 AU, 2.8 times that of a traditional carrier), the hollow heterojunction improves SO4 ‑ yield, the anti-enzymolysis time reaches 8.2+ / -0.3 h (210% of the riboflavin / UVA group), and the postoperative eye surface irritation is 0 (ISO 10993-10). The hollow virus-like nanoparticles are suitable for radical treatment of keratoconus with a corneal thickness greater than 300 mu m.

An ophthalmotonometer (100, 200) for determining a characteristic of an eye (110) is disclosed. The tonometer comprises: an execution unit (120) comprising an impingement member (130) arranged, when in use, to exert an impact on a cornea of an eye; at least one measurement unit (140, 202), a first confocal chromatography sensor (150, 204); a controller (160, 206) connected to the execution unit, the measurement unit and the first confocal chromatography sensor, where the controller is configured, in use, to: use the execution unit to apply an impact on the cornea of the eye with the impact member; determining an intraocular pressure value of the eye using at least one measuring unit; and measuring a corneal thickness value of the eye using the first confocal chromatographic sensor, where the at least one measurement unit (140) is a velocity measurement unit for measuring a velocity profile of the impact member during the impact, and the controller is further configured to determine an intraocular pressure value of the eye using the measured velocity profile.