The invention belongs to the field of external use medicine, and particularly relates to a dual-unit multi-group plaster application machine. The dual-unit multi-group plaster application machine comprises a driving roller motor, a dual-unit multi-group plaster, a driving roller A, a driving chain A, a driving roller B, a knife pressing roller speed change motor, a knife pressing roller portal frame, a rubber roller, a knife pressing roller pressure regulator, a knife pressing roller, a pressing cutting blade, a traction strip, a protective layer organizing roller, a plaster raw material pressure tank, a plaster application strip-shaped hole, a plaster application regulation switch, a plaster applicator, a plaster bearing layer organizing roller, a protection layer winding drum material, a plaster surface layer organizing roller, an auxiliary organizing roller, a winding drum material mounting rack, a bearing layer winding drum material and a plaster surface layer winding drum material. The dual-unit multi-group plaster application machine adopts the four-unit operation mode, plaster units are connected virtually and can be selected and separated, and the adaptability of the area of the plaster units of plaster carriers can be adjusted only by replacing the specifications of the knife pressing roller according to symptomatic performances and purposes of produced plasters.