The invention relates to a touch screen man-machine interactive system based on laser projection. The existing touch system based on filament lamp light source projection technology and combined with infrared mapping basically realizes man-machine interaction on a large screen, but no touch system used for laser back projection exists currently; the touch screen man-machine interactive system solves the problems that the existing touch system has a complicated structure, is not bright in color, insufficient in brightness, short in the service life of a bulb, and needs an additional infrared source, and the like; the touch screen man-machine interactive system comprises a red, green and blue (RGB) color laser light source, a laser speckle restraining module, a projection display module, a time sequence control circuit, a lens, a minicam and a projection screen; the touch screen man-machine interactive system does not need an additional infrared source, has a simple structure, high stability and is light and small equipment applicable to the man-machine interaction in museums and home entertainment; and in addition, after the minicam is shutdown and the projection display module and the time sequence control circuit are adjusted, the touch screen man-machine interactive system can also be used for displaying general movies and videos, and has good compatibility.