The invention discloses a multifunctional non-tilting cup which comprises a medicine storage cup cover, a cup body and a size-adjustable non- tilting cup holder, the medicine storage cup cover comprises a medicine cover, a medicine box and a medicine box base, the medicine box stores medicine in a separately mode through a partition plate, and the medicine cover is connected to the medicine box ina screwed mode. The medicine box base is fixed to the bottom of the medicine box, and is connected to an upper cup opening of a cup body in a screwed mode. The size-adjustable non- tilting cup holderincludes a telescopic cup body locking device and a negative pressure fixed base, a driving rotating ring is rotated, a telescopic locking plate is retracted or extended outwards, and cups of different sizes can be fixed. The negative pressure fixed base comprises a suction cup, an air bag and a sealing ring, and a sealing ring is rotated to block a lower ventilation hole C, and the suction cup is pressed to a supporting platform and the air bag is squeezed at the same time, and a negative pressure is generated in a cavity of the suction cup. The negative pressure fixed base is fixed on the supporting platform, and the sealing ring is rotated to open the lower ventilation hole C, and the air pressure inside and outside the cavity is uniform, and the adsorption is released. The multifunctional non-tilting cup integrates medicine storage, fixing different size cups and anti-tilting in one body, the functions are various, and the application range is wide.