The invention belongs to the technical field of oil field wastewater treatment, and particularly relates to an adamantine mono-quaternary ammonium salt cationic three compound combination flooding produced water oil remover, which is prepared from compounding an adamantine mono-quaternary ammonium salt cationic surface active agent, 4A zeolite, sodium carboxymethylcellulose, alcohol polyoxyethylene hydrogenated butter (11) ether and water. The adamantine mono-quaternary ammonium salt cationic surface active agent is a molecule with a long carbon chain alkyl non-polar group and an adamantyl polar group. The oil remover provided by the invention has the characteristics of simple preparation process, low cost, high temperature resistance and salt tolerance performances and good oil removing effect, the temperature resistance achieves 240 DEG C, the salinity tolerance degree achieves 240,000mg / L, and the oil removal rate reaches 97 percent or above and is improved by not less than 50 percent compared with an existing medicament. Therefore, the adamantine mono-quaternary ammonium salt cationic three compound combination flooding produced water oil remover provided by the invention can be applied in an oil removal process of three compound combination flooding produced water.