The invention discloses a multi-resonance-layer hollow-core optical fiber, which comprises an annular dielectric pipe, wherein a first type hole is formed in the central position in the annular dielectric pipe; a plurality of groups of arc-shaped dielectric layers are arranged around the first type hole, a rectangular dielectric layer is arranged on the inner side of each arc-shaped dielectric layer; a second type hole is formed between every two groups of arc-shaped dielectric layers in the same arc direction; third type holes are formed between each rectangular dielectric layer and the innerwall of the annular dielectric pipe and between each rectangular dielectric layer and the corresponding arc-shaped dielectric layer, a fourth type hole is formed between every two groups of adjacentrectangular dielectric layers, the first type hole, the second type holes, the third type holes and the fourth type holes form a low-refractive-index region, and the arc-shaped dielectric layers, therectangular dielectric layers and the annular dielectric pipe form a high-refractive-index region. The multi-resonance-layer hollow-core optical fiber has the beneficial effects that the damage threshold of the optical fiber is improved; the confinement loss of the optical fiber is reduced, and the low confinement loss features can be obtained conveniently; and high-bandwidth and low-loss opticaltransmission can be obtained in a facilitated manner.