The invention discloses a multi-user orbital angular momentum multiplexing network system, comprising an Alice control terminal, an S-D type orbital angular momentum multiplexing unit and a Bob user terminal, wherein the Alice control terminal comprises a laser source, a polarization controller, an attenuator, a first non-equal arm M-Z interferometer and an orbital angular momentum multiplexing unit; the orbital angular momentum demultiplexing unit comprises a Dammam grating, a second collimator and a single-mode fiber; the Bob user terminal comprises N Bob users; the laser source generates a light signal, the light signal is transmitted to the first non-equal arm M-Z interferometer after entering the polarization controller and the attenuator and is sequentially transmitted to the orbital angular momentum multiplexing unit and the orbital angular momentum demultiplexing unit; and finally, the light signal enters the Bob users for detection. The multi-user orbital angular momentum multiplexing network system disclosed by the invention is used for achieving one-to-many communication of quantum network communication of a free space, individual users are relatively independent, and the user number can be expanded with the increase of the orbital angular momentum multiplexing, so that the expandability is good.