The invention relates to an automobile active noise reduction and audio power amplification integrated system which comprises a main control chip, two A2B buses, an auxiliary circuit, a communication bus and an audio power amplification circuit, the main control chip is connected with the auxiliary circuit, the two A2B buses, the audio power amplification circuit and the communication bus, one A2B bus is connected with a microphone with the A2B bus, the other A2B bus is connected with the vibration sensor with the A2B bus, the communication bus is connected with a vehicle-mounted CAN signal and used for obtaining an engine rotating speed signal and a vehicle window opening signal, the microphone with the A2B bus collects a sound wave signal in a vehicle, the vibration sensor with the A2B bus obtains a vehicle vibration signal, and the main control chip performs engine noise reduction, road noise reduction and audio signal power amplification based on a vehicle-mounted CAN signal, an in-vehicle sound wave signal and an automobile vibration signal. Compared with the prior art, the system has the advantages of reduced overall cost, reduced weight and the like.