The invention relates to a monitoring mainframe box with a heat dissipation function, and the monitoring mainframe box comprises a main body, a motor, a driving shaft, a lantern ring, a fan, a damping mechanism and a fixing mechanism. The fan is fixed through the fixing mechanism, and the fan is driven to rotate through the motor, so that wind power heat dissipation is realized; vibration during motor operation is damped through the damping mechanism, compared with an existing damping mechanism, the damping mechanism has the advantages that rotation of the driving shaft is limited, meanwhile, vibration of the driving shaft is buffered and damped, practicability is improved, meanwhile, balls are clamped through fixing balls and positioning balls, the contact area with the balls is reduced, and secondary vibration caused by friction force is reduced, so that the balls roll more stably, and compared with an existing fixing mechanism, the fixing mechanism has the advantages that a bolt is doubly fixed through the threads and a fixing assembly, the problem that the bolt slips is avoided through the fixing assembly, and a better fixing effect is achieved.