The invention discloses a cooperative relay security transmission method based on artificial noise interference, wherein the whole transmission process is completed in two time slots; in the first time slot, an information source broadcasts available information fused with artificial noise to a relay and an eavesdropper, and before broadcasting, the artificial noise is pre-coded by a null space orthogonal base of a channel from the information source to the relay, and the available information is pre-coded by using a maximal ratio transmission strategy; and in the second time slot, the relay decodes and transmits the received information, and meanwhile the information source sends the artificial noise to interfere the receiving of the eavesdropper. According to the cooperative relay security transmission method based on artificial noise interference, as interferences are implemented in both the two transmission time slots for the eavesdropper, the reception signal-to-interference-and-noise-ratio of the eavesdropper can be effectively reduced, thereby the system security performance is enhanced, and the security transmission of the information is ensured; in addition, in order to improve the use ratio of the system power, the power can be set through working out the optimal power distribution factor of the system, and thereby the optimal system security performance can be achieved with the lowest power consumption.