45 results about "Bicyclic molecule" patented technology

A photochromic composition comprising (A) a polyrotaxane having a composite molecular structure composed of an axial molecule and a plurality of cyclic molecules clathrating the axial molecule and (B) a photochromic compound.

[Object] To provide a modified hydrophilic polyrotaxane which is soluble in water or a water-like solvent, a cross-linked polyrotaxane using this, and a solvent for dissolving the modified hydrophilic polyrotaxane.

[Solving Means] A modified hydrophilic polyrotaxane has a cyclic molecule, a linear molecule including the cyclic molecule with piercing through the cyclic molecule, and blocking groups which are placed at both end terminals of the linear molecule to prevent the cyclic molecule from leaving from the linear molecule. The cyclic molecule is cyclodextrin, and each of all or a part of the hydroxyl groups in the cyclodextrin is modified with a hydrophilic modification group.

A cross-linked polyrotaxane is formed by combining this modified hydrophilic polyrotaxane and a polymer through the cyclic molecule.

A solvent for dissolving this modified hydrophilic polyrotaxane contains at least one of water and a water-like solvent.

Base materials for tissue regeneration which enable the tissue regeneration, have mechanical properties needed in the tissue regeneration and can disappear via degradation in vivo after the completion of the tissue regeneration; and implantable materials with the use of the same. The above-described base materials for tissue regeneration comprise polyrotaxane, wherein biocompatible groups having bulky substituents have been introduced via hydrolyzable bond into both ends of a linear molecule penetrating plural cyclic molecules, or a polyrotaxane hydrogel having a network structure formed by crosslinking the cyclic molecules to each other, the biocompatible groups to each other, or the cyclic molecules to the biocompatible groups in each polyrotaxane molecule.

[Problems] Provided is a compound which has an antagonistic action on a muscarinic M₃ receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

[Means for Solving Problems] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M₃ receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M₃ receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M₃ receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

[Object] To provide a coating material for a room temperature curable solvent-borne overcoating material having chipping resistance and not allowing occurrence of cracks, and a room temperature curable solvent-borne overcoating material using the same, the room temperature curable solvent-borne overcoating material being excellent in abrasion resistance and in performance such as weather resistance, contamination resistance and adhesion.

[Solving Means] A coating material is formed of a lipophilic polyrotaxane including a cyclic molecule, a linear molecule piercing through the cyclic molecule to include it, and blocking groups disposed at both end terminals of the linear molecule to prevent departure of the cyclic molecule. In the lipophilic polyrotaxane, at least one of the linear molecule and the cyclic molecule has a hydrophobic modification group. A room temperature curable solvent-borne overcoating material is formed to contain the coating material preferably within a range of from 60 to 100% by mass relative to a film-forming component.

There is provided a curable aqueous overcoating composition containing 1 to 90 mass % of hydrophilic polyrotaxane with respect to the coating film forming component, where the hydrophilic polyrotaxane has a cyclic molecule, a linear molecule included in the cyclic molecule in a skewered manner and blocking groups arranged on opposite ends of the linear molecule to prevent elimination of the cyclic molecule from the linear molecule and at least one of the linear molecule and the cyclic molecule has a hydrophilic modifying group.

A curable aqueous overcoating material is obtained by blending 1-90% by mass of a hydrophilic polyrotaxane relative to the coating film-forming component. The hydrophilic polyrotaxane has a cyclic molecule, a linear molecule passing through the cyclic molecule and enclosed thereby, and blocking groups arranged on both ends of the linear molecule for preventing elimination of the cyclic molecule, and at least one of the linear molecule and the cyclic molecule has a hydrophilic modification group.

The invention provides a macrocyclic molecule, a preparation method and an application thereof. A chiral macrocyclic molecule, as the formula I or II, has the function of chiral recognition; an internal compensation macrocyclic molecule, as the formula III, has the function of recognizing a strong-hydrophilic neutral molecule.

Provided is a self-restoring macromolecular material that not only has excellent stress relaxation but that can also be easily restored to its original state, even when damaged or severed. Also provided is a method for producing the self-restoring macromolecular material. The self-restoring macromolecular material contains a crosslinked structure that is formed by crosslinking a polymer containing at least a polyrotaxane molecule. The polyrotaxane molecule is formed so as to include a cyclic molecule 21 and a linear molecule that passes through an opening 21a of the cyclic molecule. The crosslinked structure 1 is crosslinked via a reversible bond between the cyclic molecule of the polyrotaxane molecule and a polymer molecule other than the polyrotaxane molecule.

The invention discloses a preparation method of a nucleic acid targeted capture sequencing library based on a long chain molecule inversion probe. The preparation method comprises the following steps:a, synthesizing a capture probe A, a capture probe B and a connexon C; b, adding phosphorylated probes A and B and the connexon C into a ligase reaction system, simultaneously adding DNA (Deoxyribonucleic Acid) ligase so as to connect the A with the B under the bridging effect of the C; c, combining multiple connection mixtures for different target areas, and separating and purifying the connected product by denaturing electrophoresis or a nucleic acid purification kit to obtain the long chain molecular inversion probe; d, mixing the long chain molecular inversion probe with DNA or cDNA of ato-be-tested sample, hybridizing, adding DNA polymerase, DNA ligase, dNTP and a Mg2<+>-containing buffer solution into a buffer solution, extending the long chain molecular inversion probe and formingclosed molecules under the action of the DNA ligase; e, adding exonuclease to degrade non-cyclic DNA molecules; f) carrying out PCR (Polymerase Chain Reaction) amplification by using primers corresponding to a common sequence region of the long-chain molecular inversion probe to obtain the sequencing library of a targeted region.

The invention relates to a nitrogen (sulfur) containing bridge ring compound with insecticidal activity, a preparation method and an application. Specifically, the invention discloses a compound with a general formula I or an optical isomer, a cis-trans-isomer or an agricultural pharmacology acceptable salt of the compound, and a preparation method thereof, wherein R1, R2, R3, R4, R5, R6, R, m, X and Z are respectively as defined in the specification. The invention also discloses an agricultural composition comprising the above compound and an application thereof. The above compound has high insecticidal activity for homoptera and lepidoptera agriculture and forestry insects, such as aphids, plant hoppers, whiteflies, cotton bollworms, prodenia litura, armyworm, etc. The general formula 1 is shown in the specification.

The invention relates to a 6-azabicyclo (3.2.1) nonane-3-substituted derivative and a preparation method thereof, which mainly solve the technical problems that the extension of the prior endocyclic compound with 6-azabicyclo (3.23.1) nonane structure in a space structure is limited and the water solubility of the compound is poor. The reaction formula of the 6-azabicyclo (3.2.1) nonane-3-substituted derivative is shown as above. 3-nitrile-6-azabicyclo (3.2.1) nonane compound IV is obtained by adopting 6-azabicyclo (3.2.1) nonane-3-ketone III as raw materials through nitrile addition, and then the compound IV is reacted with ethanol under acid condition to generate ester compound I; or the compound III is reacted with oxyammonia, aminos, hydrazines, amides, sulfonamides, hydrazides or sulfonyl hydrazides to generate compound V, and the compound V is reduced to generate compound II.

Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.

The invention relates to a 1,3-disubstituted-3-diazabicyclo[3,3,1] nonane derivative and a preparation method thereof, mainly solving the technical problems that bridge-ring compounds with 3-diazabicyclo[3,3,1] nonane structure are limited in space structural extension, which is not good for rapid screening of compound activity and SAR analysis. The derivative disclosed herein is represented by the following formula, wherein R1 represents a protecting group of a substituted functional group or an amino group, and is selected form H, C1-C10 straight chain or one of alkyl, alkanoyl and alkylsulphonyl which contain substituent side chains; and G is one of hydroxymethyl, hydroxyl, ester, and formamido.

Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

The invention discloses an intelligent nanometer container capable of realizing reversible movement of macrocyclic molecules under stimulation of pH values and a preparation method thereof. Compared with conventional nanometer containers, the intelligent nanometer container provided by the invention has the advantages of simple operation, high sensitivity, a wide application scope, etc. The major characteristic of the intelligent nanometer container is that macrocyclic molecules can stay at different positions under different pH values. Controllable release and stage release are realized through reversible movement of macrocyclic molecules on a branched chain, so the intelligent nanometer container has good application prospects.

The invention relates to a 1,3,7-tri-substituted-diazabicyclo[3,3,1] nonane derivative and a preparation method thereof, mainly solving the technical problems that bridge-ring compounds with 1,3,7-tri-substituted-diazabicyclo[3,3,1] nonane structure are limited in space structural extension, which is not good for rapid screening of compound activity and SAR analysis. The derivative disclosed herein is represented by the following formula, wherein R1 represents a protecting group of a substituted functional group or an amino group, and is selected form H or benzyl; R2 represents a protecting group for substituting a functional group or an amino group, and is selected form H or carbobenzoxy; and G is one of hydroxymethyl, hydroxyl, ester, and formamido.

The invention relates to 3-chloro-2-chloromethyl propene, a preparation method and application thereof. The preparation method comprises the step that 1, 3-dichloroacetone is subjected to a carbonization reaction under the action of a catalyst to obtain 3-chloro-2-chloromethyl propene. According to the invention, 1, 3-dichloroacetone serves as a raw material and is subjected to a carbonization reaction under the action of a catalyst to obtain a product 3-chloro-2-chloromethyl propene in one step, wherein the raw materials are easy to obtain, the steps are simple, a large amount of wastewater is not generated in the preparation process, the method is environment-friendly, the yield of the final product is high and can reach 51-65%, and the 3-chloro-2-chloromethyl propylene can be applied to the synthesis of bridged ring compounds.

The invention relates to 1,3-disubstituted-3-azabicyclo [3,2,1] octane substituted derivates and a preparation method thereof. The invention mainly solves the technical problems that the extension of the existing bicyclic compound with a 3-azabicyclo [3,2,1] octane structure is limited in a spatial structure, thereby being not favorable for quickly screening compound activity and carrying out SAR (structure-activity relationship) analysis. The chemical structural formula of the derivates is as shown in the specification, wherein R1 is a substituted functional group or amino protecting group and is selected from H, C1-C10 linear chains or one of alkyl, benzyl, tertbutyloxycarbonyl, alkanoyl, sulfonyl, carbamide and thiocarbamide containing substituent lateral chains; and G is selected from hydroxyl, C1-C10 linear chains or one of alkoxyl, methylamino and dimethylamino containing substituent lateral chains.

The invention discloses a 3-trifluoromethyl-2,5-diazabicyclo[2.2.1] heptane derivant and a preparation method thereof, mainly aiming to solve the technical problems that bridged compounds with structure of 2,5-diazabicyclo[2.2.1] heptane are restrained in extension of a space structure, and the compounds have poor water solubility. The chemical structural formula is as follows in the specification, wherein X is NR1 or O, R1 is a functional group or amino-substituted protective group, and is selected from one of H, C1-10 linear-chain or substituent-side-chain-containing alkyl, benzyl, 2,4-dimethoxybenzyl, 4-methoxybenzyl, tertiarybutoxy carbonyl, carboxybenzyl, alkylacyl, aroyl, alkylsulfonyl or aryl sulfonyl, and R2 is a functional group or amino-substituted protective group, and is selected from one of H, C1-10 linear-chain or substituent-side-chain-containing alkyl, benzyl, 2,4-dimethoxybenzyl, 4-methoxybenzyl, carboxybenzyl, alkylacyl, aroyl, alkylsulfonyl or aryl sulfonyl.

The invention belongs to the interdisciplinary field of inorganic chemistry and organic chemistry and discloses preparation of a macrocyclic molecule-modified nano silica capillary chromatographic column. Nano silica is modified first with silylation reagent APTS, macrocyclic molecules are then reacted with dichloride oxalate, separating and purifying are carried out to obtain macrocyclic molecule acyl chloride, and the macrocyclic molecule acyl chloride is then reacted with the modified nano silica to obtain the macrocyclic molecule-modified nano silica; the macrocyclic molecule-modified nano silica is charged into a capillary chromatographic column through a column charging pump, nitrogen flushing is carried out, and the temperature 280 DEG C is held for 12 h to obtain the capillary chromatographic column. The capillary chromatographic column prepared herein has an important application prospect in terms of separation, purification and chiral enantiomer separation.