33 results about "DNA Methyltransferase Inhibitor" patented technology

The invention discloses a medical application of DNA methyltransferase inhibitor combined with anti-CD47 antibody for preparing antineoplastic drugs, which will be appreciated by those skilled in theart, CD47 in physiological state can maintain the immune tolerance of the body's own cells, and in pathological state, it can be overexpressed in a variety of hematological tumors and solid tumors, through the combination of phagocyte ligands to initiate a series of inhibitory signal transduction to avoid phagocytosis, and inhibit the presentation of tumor antigens phagocytes, anti-CD47 antibody has anti-tumor effect. However, anti-CD47 antibodies alone are expensive and have limited efficacy. DNA methyltransferase inhibitors play an anti-tumor role by restoring the activity of tumor suppressor genes. As that DNA methyltransferase inhibitor and the anti-CD47 antibody combine to exhibit obvious synergistic effect on anti-tumor, the DNA methyltransferase inhibitor and the anti-CD47 antibodycan be combined to be use for anti-tumor, thereby enhancing the anti-tumor effect of the anti-CD47 antibody and reducing the economic burden of the patient.