The invention relates to an image deblurring method based on fuzzy region segmentation, and the method comprises the following steps: S1, taking a peak measure to distinguish a fuzzy region B and a non-fuzzy region U so as to represent the feature difference; S2, segmenting the fuzzy region B and the non-fuzzy region U through a Graph-cut algorithm; S3, carrying out the estimation of an original image region L for the fuzzy region B; S4, carrying out the estimation of a fuzzy kernel k of the fuzzy region B; S5, carrying out the image deconvolution of the fuzzy region B, and obtaining a clear region; S6, carrying out the fusion of the clear region and the non-fuzzy region U again, and obtaining a final deblurring result. According to the invention, the fuzzy region and the non-fuzzy region of a fuzzy image are segmented, and the estimation of the original image region and the fuzzy kernel for the fuzzy region is carried out and then the image deconvolution is carried out, thereby achieving the deblurring of the fuzzy region and obtaining the clear region. The clear region is combined with the former non-fuzzy region, and a final deblurring result of the fuzzy image is obtained, thereby effectively improving the efficiency and shortening the time.