The invention relates to the technical field of digital information transmission, and discloses a ZigBee-Bluetooth communication implementation method, which comprises the following steps of: step 1, judging sampling clock skew and estimating the sampling clock skew; step 2, sampling clock offset compensation; step 3, matching the lead code with the access address; step 4, processing received data; and step 5, processing the effective load information by the Bluetooth upper layer protocol. On the premise that communication between Bluetooth is compatible, cross-protocol communication of the Bluetooth receiver to ZigBee-Bluetooth is achieved, and compatibility of a Bluetooth upper-layer protocol and a fault-tolerant mechanism of cross-protocol communication are achieved through mechanisms such as codebook mapping and the like; reasonable sampling clock skew compensation is carried out according to sampling clock skew judgment and sampling clock skew estimation results, so that the modification degree of hardware of a receiving end is reduced; and due to the certainty of the sampling offset of the receiver, the calculation cost of the codebook mapping mechanism of the Bluetooth receiver is one fourth of that of cross decoding, and the receiving calculation cost and the matching cost of the Bluetooth receiver are greatly reduced.