The invention relates to an information material file storage box with a secret, high-guarantee and real-time tracing function. The information material file storage box comprises an MCU module, a fingerprint module, a promoting module, a self-destroying control module, a damp-proof module, a positioning module, a fixed clamp and a self-destroying material, wherein The MCU module controls the damp-proof module to perform constant-temperature control and dehumidifying control to eliminate influences of environment temperature and humidity in a transportation process, so that the temperature is controlled to be about the standard temperature of 20 DEG C, and humidity is controlled to be about 50% of optimum humidity; the fingerprint module, the prompting module and the positioning module are combined, so that the box is controlled to open safer; moreover, a state of the box is known in real time through a corresponding hand ring or mobile phone; while finding that the box is missing, information transmitting staff can immediately perform positioning and tracing on the information file box in a mode of enabling the worn hand ring or mobile phone to match with a remote control terminal; the self-destroying control module can be combined with the self-destroying material to realize a self-destroying function, so that information files are destroyed from the moment that box is self-destroyed and opened only within 2 seconds, and therefore, greater loss caused by missing of the information material file storage box can be prevented.