The invention discloses a plasma disinfection device for mobile phones. The plasma disinfection device comprises a shell, a supporting rod, a support, a telescopic rod, a fixed seat, a main switch, a power line socket, a control panel, an emergency stop switch, an LED display screen, an LED indicator light, control keys, a tray fixed plate, a handle, a mobile phone placing tray, a sensor, a slide strip, a slide rail, a vertical partition plate, a threading hole, a horizontal partition plate, a shell rear plate, electronic control components, a PLC, a relay, a MeanWell power supply, a circuit board of a control circuit, a bottom surface of the shell, and the like. The plasma disinfection device is good in disinfection effect, and the electrical damage and physical damage on the mobile phones are reduced. Generated plasma is more uniform and more stable, and different sizes of the mobile phones are accurately positioned through the cooperation of a servo motor and the sensor, so that every mobile phone can be disinfected in an optimal disinfection area.