The utility model discloses a pipeline sealing connection structure which comprises a first pipeline, a second pipeline, first limiting columns, a first sealing ring, second limiting columns, a second sealing ring, a sealing sleeve, first limiting grooves, an anti-rotation boss and second limiting grooves. A first sealing ring is installed on the portion, located on the outer side of the first limiting column, of the first pipeline through a sealing groove, second limiting columns are fixedly connected to the second pipeline in a vertically symmetrical mode, a second sealing ring is installed on the outer portion of the side, close to the first pipeline, of the second pipeline through a sealing groove, and the first pipeline and one end of the second pipeline are sleeved with the sealing sleeve. Two first limiting grooves are evenly formed in the upper portion and the lower portion of the end, close to the first pipeline, of the sealing sleeve, and anti-rotation bosses are integrally arranged at one ends of the two first limiting grooves correspondingly. The connecting device is simple and reasonable in structure, quick and convenient to connect, good in sealing performance, low in manufacturing cost and high in practicability.