The invention discloses a hand-held multi-degree-of-freedom controllable intervention guide wire and an intervention device. The intervention device includes: a handle housing, a control module, buttons, bearings, a multi-degree-of-freedom controllable intervention guide wire, and a rigid sleeve. , Driven wheel, driving wheel, driving motor, bit seat, transition wheel, bit wheel, wire, battery, plug. The multi-degree-of-freedom controllable interventional guide wire includes: a soft sleeve, a hydrophilic layer and a head end; wherein, the hydrophilic layer is located on the outer layer of the sleeve; the entire guide wire can be divided into an active bending section and a non-active bending section , a spring is embedded in the hydrophilic layer of the active bending section to provide the recovery stiffness of the guide wire bending. The guide wire further includes: a front torsion shaft, a front limit ball, a front limit plate, a front twist rope, a middle twist rope, a middle limit plate, and a middle torsion shaft arranged inside the casing. The invention can accurately reproduce the surgeon's manual operation, assisting the surgeon to more efficiently and safely complete the task of diagnosing and treating patients.