The invention discloses a blast-furnace smelting method for vanadium titano-magnetite. The method is realized in a way that: vanadium titano-magnetite accounts for 30-60% of ferrous burden which is fed into a blast furnace, and the burden comprises 40-65% of agglomerate, 30-50% of pellet and 5-10% of lump ore; the diacidic basicities CaO/SiO2 of agglomerate, pellet and blast-furnace slag are respectively controlled at 1.6-2.5, 0.6-1.0 and 1.05-1.20; the content of MgO in blast-furnace slag is controlled at 7.5-9.0%; by adding two batches of ore and three batches of coke and using the charging operation of the development center, manganese oxide ore or sintered manganese ore powder, and fluorite are incorporated into injection coal and injected into the blast furnace along with the coal powder; and thus, the content of MnO in the slag and the content of CaF2 in the slag are respectively controlled at 1.0-4.5% and 0.50-2.0%, and the oxygen-enrichment percentage of the blast furnace is controlled at 2.0-4.0%. Compared with the smelting blast furnace using the same quality and structure of the burden, the comprehensive coke ratio of the invention is reduced by 20-50kg per ton of iron, the content of TFe in the slag is reduced by 50%, and the comprehensive cost per ton of iron is reduced by 30-50 yuan. The invention has wide prospects for popularization and application.