The invention discloses a large-cross section metal shielding flexible cable for mobile equipment. A fiber weaving reinforcement layer, a twist-resistant sheath layer and a wear-resistant layer are sequentially arranged outside a cable core, the cable core comprises an insulation power line core group, a deformable ground wire core and a control line core group, the insulation power line core group comprises three or more than three power line cores, the deformable ground wire core is formed by stranding a tin-plated flexible conductor, the control line core group sequentially comprises a control cable core, an isolation layer, a metal shielding layer and a sheath layer from inside to outside, the control cable core is formed by stranding three or more than three insulation line cores, andthe power line cores and the control line core group wrap the deformable ground line core and are stranded to form the cable core. The large-cross section metal shielding flexible cable has excellentcapability of bending resistance, grinding resistance, twist resistance, extrusion resistance, wear resistance, interference resistance and interference prevention, the service lifetime of the existing current is remarkably prolonged, and the production safety is improved.