The invention discloses a plastic bag double layer opening folding sealing system. The plastic bag double layer opening folding sealing system is structurally comprises a lifting handle ring, a machine body, a lifting base, a conveyor, guiding wheels, a guiding rubber belt, a driving guiding wheel, a cooling block, a heating block, a conveying belt, a driven wheel, a sealing guiding plate, a protection cover and a controller. The bottom face of the machine body is fixedly connected with the top face of the lifting base. One end face of the lifting base is connected with the conveyor. Accordingto the plastic bag double layer opening folding sealing system, the system is provided with the lift base and thus has the height adjusting function, the height of the machine body can be adjusted sothat the system can adapt to plastic bags with different heights, thus, sealing of plastic bags with different heights is achieved, the application range of the system is enlarged, and the system utilization rate is increased advantageously.