The invention provides a method and device for automatic registration of a three-dimensional
skull. In the invention, an
edge type classifier is trained firstly, then
edge extraction is performed on a three-dimensional
skull to be registered to obtain three-dimensional hole edges, shape distribution features of all three-dimensional hole edges are extracted, the three-dimensional hole edges are automatically classified into
orbit edges,
nose frame edges and the like by adopting the
edge type classifier, then PCA (
Principal Component Analysis) is performed on all edge points on the
nose frame edges so as to determine a unified coordinate
system, adjustment is performed on the initial position and posture of the three-dimensional
skull to be registered, then registration of an
edge region is realized according to a corresponding relationship between the three-dimensional skull to be registered and a reference skull edge by adopting a CPD (Coherent Point Drift)
algorithm, and finally adjustment is performed on a region with a great registration error of the three-dimensional skull to be registered and the reference skull by adopting a CSRBF (Compact Support
Radial Basis Function) so as to achieve accurate registration of the three-dimensional skull to be registered and the entire skull region of the reference skull.