2 results about "Genetic modulation" patented technology

The present disclosure relates to compositions including or obtained from genetically modified bacterial host cells (e.g., E. colt) and methods for using the same for cell-free bacteriophage synthesis (CFBS). In particular, the present technology relates to genetically modified E. coli that overexpress one or more of translation initiation factor IF-3 (infC), OxyS and CyaR and / or repress RecC subunit exonuclease RecBCD, and methods for using the same to obtain improved CFBS yields.

Disclosed are abasic modification structures that can be incorporated into oligonucleotides to effectively modulate the expression of a target gene in a subject while mitigating off-target specificity. Also disclosed are gene modulators and pharmaceutical compositions comprising the abasic modification structures, as well as methods of using the structures to modulate the expression of a target gene while mitigating off-target specificity.