62 results about "LAG3" patented technology

The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and / or treating an infectious disease with such molecules are provided.

The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.

The invention relates to LAG-3 binding agents, in particular particularly variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.

A method for classifying patients at risk for cardiovascular disease, other chronic inflammatory diseases, cardiovascular and / or non-cardiovascular morbidity and mortality based on a risk assessment for lymphocyte activation gene 3 (LAG3) protein deficiency, and for mediating the risk using recombinant lymphocyte activation gene-3 or LAG3 mimetic as a companion therapeutic alone or in combination with a statin and / or an anti-hyperlipidemic drug. The risk assessment is two-prong, beginning with a qualitative determination whether a subject has or is predisposed to abnormal expression of inflammasomes, heightened risk for inflammation and / or to dysfunctional HDL, followed by a quantitative assay or genetic screen for a polymorphism that occurs in the coding sequence of the LAG3 gene. Given positive indication, recombinant LAG3 and / or LAG3 mimetic is used alone or in combination with the therapeutic use of a cholesterol mediating drug for treatment.

The invention relates to LAG-3 binding agents, in particular particularly variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.

The present invention relates to the identification of fibrinogen like protein 1 (FGL1) as a prognostic biomarker for responsiveness to an immune checkpoint inhibitor in a cancer patient. More specifically it relates to methods of treating cancer in a human patient comprising administering an immune checkpoint inhibitory antibody specifically inhibiting the interaction of fibrinogen-like protein 1 (FGL1) with lymphocyte-activation gene 3 protein (LAG3), wherein the cancer is an FGL1 expressing cancer. Further, the invention relates to methods for assessing susceptibility or predicting the responsiveness to the treatment with an immune checkpoint inhibitory antibody specifically inhibiting the interaction of FGL1 with LAG3 in a cancer patient, comprising detecting FGL1 expression in a sample from said patient and to a kit for selecting a cancer patient that would benefit from an immune checkpoint inhibitory antibody specifically inhibiting the interaction of FGL1 with LAG3. The immune checkpoint inhibitory antibody that specifically inhibits the interaction between FGL1 and LAG3 may be an antibody directed against human FGL1 or an antibody directed against human LAG3, optionally in combination with other immune checkpoint inhibitory antibodies, such as an anti-PD1 or an anti-PD-L1 antibody.

The present invention relates to a FGL1 antibody or an antigen-binding fragment thereof. The FGL1 antibody or its antigen-binding fragment has high binding activity to FGL1 protein, and can realize the blocking of the binding of FGL1 protein and LAG3 protein, and the combination of FGL1 protein and expression. Blockade of cellular binding of LAG3 protein. The present invention also relates to a nucleic acid encoding the FGL1 antibody or an antigen-binding fragment thereof; a cell containing the nucleic acid; a composition containing the FGL1 antibody or an antigen-binding fragment thereof, the nucleic acid, the cell; containing the FGL1 Kits for antibodies or antigen-binding fragments thereof, nucleic acids, and compositions; and the FGL1 antibody or antigen-binding fragments thereof, nucleic acids, and compositions in the preparation of reagents for detecting, diagnosing tumors, or treating tumors. application in medicine.

The invention discloses a novel model for prognosis prediction and diagnosis of colorectal cancer and application thereof, the model comprises immune related markers CCL11, CCL19, CCL22, CCL28, CXCR5, IDO1, LAG3, TIM4, HSPA1A, HSPA8, HSPA9, NOS2 and TGF beta1, the prognosis of a subject can be accurately predicted according to the model, the model provides a reliable prognosis prediction and diagnosis marker for evaluation of a patient with colorectal cancer, and the model can be applied to the prognosis prediction and diagnosis of the patient with colorectal cancer. The evaluation and prediction capability of prognosis prediction and diagnosis of the colorectal cancer patient is improved, and the application prospect in clinic is wide.

The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey LAG3 as well as immunoglobulin chains thereof and polynucleotides encoding the same along with injection devices comprising such antibodies or fragments. Vaccines including such antibodies and fragments as well as compositions comprising the antibodies and fragments (e.g., including anti-PD1 antibodies) are included in the invention. Methods for treating or preventing cancer or infection using such compositions are also provided. In addition, methods for recombinant expression of the antibodies and fragments are part of the present invention.