The invention discloses a differential clock tree circuit for a high-speed multi-channel interface bus. The differential clock tree circuit for the high-speed multi-channel interface bus has the characteristics of being low in jitter, simple in structure, capable of being cascaded and high in anti-noise capability, and long-distance transmission of a high-speed clock can be achieved. The highly symmetric full analog differential clock tree circuit of the invention has the characteristics of being low in jitter, simple in structure, capable of being cascaded and high in anti-noise capability, and long-distance transmission of the high-speed clock can be achieved. A cascade circuit formed on the basis of the differential clock tree circuit is of a full differential structure, the differential structure appears in pairs and has strong ability to suppress noises; secondly, the structure adopted by the differential clock tree circuit is a differential input/output structure form, which canrealize cascading; thirdly, a field-effect transistor is used for bias power supply, thus noises on the power supply and ground can be shielded, and the low-jitter characteristics can be realized; andfinally, a collector series resistor of a transistor is adopted to reduce the swing amplitude of a differential signal, the driving capability is high, and long-distance transmission can be realized.