The invention discloses a driving method of an LED spherical screen, and relates to the technical field of LED display driving. The method comprises the following steps: 1, dividing a display spherical surface into a top display area, a bottom display area and a plurality of side display areas, and calculating display parameters of each display area; 2, generating a rectangular video image; 3, carrying out the geometric deformation from a plane to an arc surface on the rectangular video image in the step 2, and carrying out the image compression processing after deformation; 4, intercepting the video image subjected to compression processing in the step 3; 5, distributing the video images intercepted in the step 4 to the display areas divided in the step 1, and splicing the video images distributed in the display areas into a spherical video image picture capable of being continuously displayed. According to the invention, the video images are effectively utilized, the transition display effect among the display areas is smooth, no chromatic aberration exists between the display areas, the tolerance degree of the compressed image is increased, and the driving efficiency of the image is improved.