Crosslinked
polymer particles that are useful as an adsorbent, or carrier thereof, for treatment of a liquid containing physiological substance and / or cells, etc., such as
body fluid, and that is reduced in the activation of
complement system and leukocytes; and a process for producing
polymer particles being useful as an adsorbent / treating material, or carrier thereof, for treatment of
body fluid. In particular, there are provided crosslinked
polymer particles comprising as a constituent a
polymerization unit containing a
vinyl alcohol unit and
nitrogen-containing
polymerization unit, wherein the content of
nitrogen base on the whole weight of grains in the dry state as determined by elementary analysis is in the range of 7.0 to 13.0 weight %, and wherein the surface
nitrogen content determined by X-
ray photoelectron
spectroscopy (XPS) is in the range of 5.0 to 15.0 at %. Further, there are provided crosslinked polymer particles of 50 to 3000 μm
volume average particle
diameter, of which ≧80 volume % particles have a
diameter of 0.8 to 1.2 times the
volume average particle
diameter, obtained by first forming liquid drops of uniform diameter consisting of a
monomer mixture in a dispersion medium and subsequently polymerizing the liquid drops under conditions avoiding cohesion or additional dispersion thereof, optionally further conducting treatment or modification; and is provided a relevant process for producing polymer particles.