The invention belongs to the technical field of a traditional Chinese medicine, particularly relates to a painless quick-acting coaptation medicine which comprises the following raw materials according to the parts by weight: 5 to 25 of mastic, 5 to 35 of native copper, 5 to 10 of aconite root, 5 to 10 of myrrh, 5 to 10 of woodlouse, 5 to 10 of panax notoginseng, 5 to 10 of earthworm, 5 to 10 of safflower, 5 to 10 of borneol, 1 to 5 of angelica root, 1 to 5 of cortex mori radicis, 1 to 5 of radices paeoniae rubra, 0.5 to 1 of vermilion and 1 to 2 of pearl powder. The painless quick-acting coaptation medicine contains no valuable materials, can lead patients to achieve the effects of quick acesodyne, detumescence, coaptation, tendon relaxtion, activeation of blood circulation and stasis elimination and is suitable for various diseases of fracture, blood stasis, sore pain, injuries from falls, and the like. Compared with the like product, the painless quick-acting coaptation medicine has the advantages of quick action, effective treatment, high cure rate, short convalescence, no side effect, and the like, and achieves the total effective rate of 97 percent.