The invention relates to a material warehouse-in warehouse-out management system based on LoRa network, comprising a server warehouse-in unit, a warehouse-out unit and a plurality of mechanical shelves. The server is connected with a mobile phone terminal and a management PC terminal. The warehouse-in unit comprises a warehousing terminal, wherein the warehouse-in terminal is connected with a warehousing two-dimensional code scanner, a warehousing keyboard, a warehousing display, a material information acquisition device, a warehousing conveyor belt driving motor, an X-ray security inspectionmachine and a two-dimensional code generator; The warehouse-out unit comprises a warehouse-out terminal machine, wherein the warehouse-out terminal machine is connected with a warehouse-out two-dimensional code scanner, a warehouse-out keyboard, a warehouse-out display, a warehouse-out conveyor belt driving motor, a camera, a fingerprint recognizer and a printing terminal; The invention has the advantages of convenient data storage, high safety, convenient management, saving manpower and effectively reducing labor intensity.