The invention discloses a control method of a heat dissipation system of a high-capacity generator set. The method comprises the following steps: when a rotating wheel drives a rotor to rotate to generate electricity, a rotating shaft on the rotor driving centrifugal fan blades to rotate, so that cold air at the air inlet end is sucked in, flows out in the radial direction through vent holes in amagnet yoke, is sprayed to a stator to absorb heat to become hot air, and is exhausted outwards through the air outlet end; detecting a temperature difference delta T between the air outlet end and the air inlet end, and comparing the temperature difference -T with a set temperature difference delta T; when -T is less than or equal to 0.95[delta]T, reducing the friction force between the rotatingshaft and the centrifugal fan blades to reduce rotating speed of the centrifugal fan blades, and when -T is larger than or equal to 1.05 [delta T, increasing the friction force between the rotating shaft and the centrifugal fan blades to increase the rotating speed of the centrifugal fan blades, and when -T is larger than or equal to 0.95 [delta]T and smaller than 1.05 [delta]T, keeping the friction force unchanged. Ventilation loss can be remarkably reduced, the heat dissipation and cooling efficiency is improved, uniform heat dissipation of the generator set is ensured, and the complex structure of a heat dissipation system is avoided.