The invention relates to a multi-factor coordinated energy-saving optimization control method of a greenhouse environment. The method comprises: (1), an expected daily average temperature of the crop in each growth period is set and weather forecast data of next seven days are obtained; (2), a greenhouse ventilation system state is estimated; (3), setting values of all environmental factors in the greenhouse are set by using a multi-factor coordination algorithm according to the steps (1) and (2), wherein the environmental factors include a temperature, humidity, a light radiation intensity and carbon dioxide concentration; and (4), real-time environmental factor values are obtained and corresponding executing mechanisms in the greenhouse are regulated according to the environmental factor setting values. Compared with the prior art, on the basis of crop physiological properties like temperature accumulation, the energy consumption of the greenhouse can be reduced effectively. With corresponding strategies, secondary greenhouse environment factors are coordinated to main temperature factors equivalently, thereby guaranteeing the precision and efficiency of greenhouse regulation, avoiding unnecessary energy wasting, saving the regulation cost, and ensuring the precise and effective controlling.