4 results about "Bruch's membrane" patented technology

Retinal layer segmentation in optical coherence tomography (OCT) data is improved by using OCT angiography (OCTA) data to enhance a target retinal layer within the OCT data that may lack sufficient definition for segmentation. The OCT data is enhanced based on a mixture of the OCT data and OCTA data, such that contrast in the OCT data is enhanced in areas where OCT and OCTA data are dissimilar, and is reduced in areas where the OCT and OCTA data are similar. The target retinal layer in the OCT data is segmented based on the enhanced data. Two en face images of the OCTA data that include the target retinal layer are used to check for errors in the segmentation of the target retinal layer in the OCT data. Identified errors are replaced with an approximation based on the locations of top and bottom retinal layers of one of the en face images.

The present invention provides a method of a prophylaxis or a treatment of a pathological change of Bruch's membrane and / or an adjacent tissue, including a retinal pigment epithelium, a choroid, and an optic nerve head of an eye, e.g. a calcification of Bruch's membrane and / or the adjacent tissue, using a nanoparticle comprising a scaffold comprising a biodegradable material, an antibody targeted to a component of a Bruch's membrane, a component of a sub-retinal pigment epithelial deposit, or a component of an optic nerve head, and an anti-calcifying agent. Additionally, the present invention provides a pharmaceutical composition comprising said nanoparticle and one or more pharmaceutical acceptable excipient(s). Said pharmaceutical composition could be used in a method of prophylaxis or treatment of a pathological change of Bruch's membrane and / or adjacent tissues, including a retinal pigment epithelium and a choroid of an eye and / or a calcified sub-retinal pigment epithelium deposit and / or a calcified drusen.

The present invention is directed to compositions for oral administration comprising two or more active ingredients selected from the group consisting of quercetin, metabolites, derivatives and salts and hydrates thereof, a kaempferol rutinoside and salts and hydrates thereof, indole-3-carbinol and derivatives and metabolites and salts and hydrates thereof and gallic acid and salts and hydrates thereof. The present invention is further directed to methods for treating dry eye disease, treating age-related macular degeneration, increasing Bruch's membrane stiffness, modulating expression of a gene selected from the group consisting of YAP, TAZ, integrin α5, integrin β5, interferon β1, interleukin-6, C-X-C motif chemokine ligand 1, C-X-C motif chemokine ligand 10, and combinations thereof, increasing adhesion of retinal pigment epithelium cells to a Bruch's membrane, and methods of modulating a secretory profile of senescent cells exhibiting the senescence-associated secretory phenotype comprising administering an effective amount of one or more active ingredients selected from the group consisting of kaempferol derivatives and salts thereof and hydrates thereof, quercetin metabolites, derivatives and salts and hydrates thereof, indole-3-carbinol and derivatives and metabolites and salts and hydrates thereof and gallic acid and salts and hydrates thereof to a subject in need thereof.

The invention relates to a brooch membrane opening detection method, electronic equipment and a medium, and belongs to the technical field of biomedicine, and the method comprises the following steps: obtaining target body data of a retina area; based on a first pre-training detection model, extracting an optic disk center point in the target body data; based on the optic disk center point, performing radial sampling on the target body data to obtain a plurality of target images; and inputting the plurality of target images into a second pre-training detection model to obtain the brooch membrane opening point. Strong anatomical priori is introduced for the detection model based on radial sampling of the optic disc center point, so that the detection model is more easily focused in a correct area, interference of speckle noise is resisted, and the Brooch membrane opening detection precision is improved.