The invention provides a novel great-circle celestial coordinate system with six regions, which belongs to the field of astronomy basic theories. The building of a traditional celestial coordinate system is related to theories of earth rotation, south and north poles and parallel circles, wherein the parallel circles are small circles, and the problems that longitude in polar regions is difficult to distinguish and a celestial sphere is divided non-uniformly as a longitude plotting scale deforms along with latitude. According to the novel great-circle celestial coordinate system with the six regions, the celestial sphere is divided into six identical regions, each novel coordinate is constructed by a great circle completely, the coordinate relations between each region and an equatorial system of coordinate as well as each region and a space rectangular coordinate are deduced, and formulas of the relation are concise. The novel great-circle celestial coordinate system is defined intuitively, treats six celestial sphere regions equally, can not be influenced by the south and north poles and the parallel circles, is more uniform in region division, does not increase calculation complexity of coordinate conversion, and is suitable for popularization. With the devolvement of the south and north poles and the satellite orbit design, in particular to constant expanding of the deep space exploration filed, the novel coordinate system has potential application value.