The invention relates to a regional power grid load prediction method and device based on heterogeneous meteorological data fusion, which belong to the technical field of electric power, and solve the problems of low power grid load prediction accuracy and low power grid load prediction speed caused by existing meteorological data. The method comprises the following steps of determining meteorological data influencing a load in each meteorological sub-region in a regional power grid, wherein the meteorological data comprises cloud picture data shot by an all-sky imager, preprocessing the meteorological data, establishing a cloud picture classification and discrimination model of a Gabor filter-convolution automatic encoder, and performing prediction and classification processing on the preprocessed cloud picture data by using the discrimination model, fusing the classified cloud picture data and other meteorological data to form a meteorological data set, wherein the other meteorological data comprise air pressure, temperature, precipitation, relative humidity, wind speed, wind direction, date type and cloud picture data, establishing a load prediction model, and predicting the load of each meteorological zone by using the load prediction model. And the accuracy and speed of load prediction are improved.