The invention discloses a high-resolution universal display screen intelligent control system, which comprises a control unit, at least two transmitting units and at least two groups of receiving units which are sequentially connected. The control unit is provided with a first preset value input end, a video conversion module and a first distribution module, presets the screen body resolution of an LED screen, converts a video file into video signal data, divides the data into at least two groups of data according to the number of the transmitting units, performs batch processing on the data through a video output interface and correspondingly transmits the data to each transmitting unit. Each transmitting unit is provided with a first automatic identification module, a processing module and a second distribution module, automatically identifies the screen body resolution, generates control signal data, divides the data into groups, and transmits the data to each corresponding receiving unit respectively. Each receiving unit controls the LED screen through at least three data output ports. The high-resolution universal display screen intelligent control system intelligently identifies the LED screen body resolution, can control a high-resolution large-area LED screen by only one set of control system, and has the advantages of simple control mode and lower cost.