The invention relates to a self-service goods inspection method, and the method comprises following steps: S1, a commodity barcode of a commodity put in a goods warehouse is scanned, a commodity barcode information List is obtained, and synchronously, goods weighed weight C of goods in the goods warehouse is weighed; S2, goods weight K is read from a goods database according to the commodity barcode information List; S3, whether an error between the weight K in the goods database and the goods weighed weight C is in a setting range is judged, if yes, the verification passes, and if not, the verification fails. The invention also correspondingly relates to a self-service goods inspection system. According to the invention, operating cost of a supermarket can be greatly reduced, the operation efficiency of the supermarket can be improved, a supermarket cashier can be replaced by a robot, and successful operation of unmanned supermarket is possible.