The invention discloses a 3D printing intelligent monitoring system. The 3D printing intelligent monitoring system comprises a data monitoring module, a vision monitoring module, a 3D printing module,a 3D printing database, a cloud service platform, a warning module and an intelligent terminal, wherein the input end of the cloud service platform is separately connected with output ends of the data monitoring module, the vision monitoring module, the 3D printing database and the intelligent terminal, the data monitoring module comprises a temperature monitoring unit, a humidity monitoring unitand an operation monitoring unit, the vision monitoring module comprises an image acquisition unit, an action capturing unit and an anti-interference unit, the cloud service platform comprises a central processing unit, an information transceiving unit, a storage unit and an execution unit, and the intelligent terminal comprises a display unit and an input unit. By adopting the 3D printing intelligent monitoring system, the printing process can be conveniently monitored, the problems can be discovered and treated in time, the cost is reduced, and the material waste is avoided; and the invention also provides an application method of the 3D printing intelligent monitoring system. The 3D printing intelligent monitoring system is convenient and rapid in operation and convenient in popularization.