The invention relates to a disease preventing and treating agent for snakegourd. The disease preventing and treating agent is prepared from the following components in parts by weight: 10 to 15 parts of Lithospermum erythrorhizon, 20 to 25 parts of common sage herb, 10 to 15 parts of prunella vulgaris, 2 to 5 parts of Coptis chinensis, 0.2 to 0.5 part of radix sophorae flavescentis, 1 to 2 parts of cortex phellodendri, 5 to 8 parts of garlic bulb, 2 to 3 parts of dandelion, 2 to 3 parts of white gourd seed, 1 to 2 parts of cassia seed, 0.1 to 0.2 part of copper sulfate, 0.05 to 0.08 part of manganese chloride, 0.02 to 0.03 part of inositol, 50 to 80 parts of a thiophanate methyl wettable powder 500-times-diluted solution with a concentration of 50%, 30 to 50 parts of a chlorothaloni wettable powder 500-times-diluted solution with a concentration of 75% and 30 to 50 parts of a carbendazim wettable powder 500-times-diluted solution with a concentration of 50%. According to the invention, traditional Chinese medicinal extracts are rich in bactericidal and disinfectant effective components, have good preventing and treating effects on diseases of the snakegourd, reduce the proportion of a chemical agent at the same time, and decrease the toxicity of the agent on the premise of guaranteeing that the cure rate of the diseases is not affected, so the fruit bearing rate of the snakegourd is effectively guaranteed; meanwhile, effective components in the inositol and traditional Chinese medicines have the function of promoting fruit bearing of the snakegourd, so significant effects of increasing yield and revenue for snakegourd planters are achieved.