The invention discloses a fresh air purification all-in-one machine, which comprises a casing, an indoor air return inlet, an outdoor fresh air inlet, a fresh air supply opening, an indoor air return exhaust opening and a power supply control device, wherein the power supply control device is arranged in the casing; a primary filter, a heat exchange core body, an exhaust machine, a secondary filter, an ion cloud dust removal module, an air supply machine and a tertiary filter are sequentially arranged in the casing; the exhaust machine, the ion cloud dust removal module and the air supplying machine are respectively and electrically connected with the power supply control device. The outdoor air and the indoor air are simultaneously introduced into a purifier; the air circulation is realized; the indoor air quality is improved; in addition, the ventilation and the air purification function are integrated; the plug-and-use effect is achieved; the problems of installation and repair difficulty and house structure damage by pipelines installing are solved; the ion cloud generating device can ionize outdoor air to generate negative ions; dust is adsorbed onto a dust collecting plate after being charged. The fresh air purification all-in-one machine has the advantages that the negative ion generating quantity is great; the conveyance distance is long; the dust removal and sterilization effects are good; in addition, no ozone is generated in the work process; the environment is protected; health is realized.