The invention relates to the technical field of medical instruments, in particular to a cardio-pulmonary resuscitation rescue device for the cardiology department. The device comprises a device body; an oxygen inhalation assembly is arranged on one side of the top of the device body and comprises an oxygen collecting bin fixedly connected with one side of the top of the device body, a defibrillation assembly is arranged on the top of the side, close to the device body, of the oxygen collecting bin, a pillow is arranged on the side, close to the oxygen inhalation assembly, of the top of the device body, moving assemblies are arranged in the middle of the two ends of the device body, each moving assembly comprises a second sliding groove, and a pressing assembly is slidably arranged in the second sliding groove. Through mutual cooperation of the moving plate, the threaded rod, the first fixing plate, the through groove, the first sliding groove and the second sliding groove, the position can be adjusted by moving the moving plate and the pressing assembly so that the device can be adjusted to the pressing position most suitable for a patient according to the height of the patient, and secondary damage to the patient by the device is avoided.