16 results about "Analogues/Derivatives" patented technology

The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to mustard-based alkylating agents such as uracil mustard and analogs, derivatives, or prodrugs thereof, including 6-methyluracil mustard and 6-ethyluracil mustard.

The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

Provided herein include compounds, compositions, kits and methods for preventing and treating psychiatric disorders. The composition and methods described herein can prophylactically treat a subject prior to and / or after a stressor and / or prior to the recurrence of a stressor, thereby preventing or delaying a relapse of depression or depression-like and / or stress-induced behaviors and disorders. The composition can comprise a serotonin 4 receptor (S-HUR) agonist and an N- methyl-D-aspartate (NMDAR) antagonist and a pharmaceutically acceptable salt, analog, derivative or metabolite thereof.

A method for treating breast cancer comprises a combination of a therapeutically effective amount of irsidin or an irsidin analog, derivative, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of a PARP inhibitor. The composition and kit are included herein. Breast cancer can be refractory to various PARP inhibitors.

The present disclosure generally relates to a process of preparation of heteroaromatic compound which essentially acts as anti-diabetic agent and their analogues / derivatives thereof. The invention specifically relates to a process of preparation of Imeglimin compound, and its analogues, derivatives, isomers and salt forms thereof of Formula I, by using a heterogeneous catalyst or ion exchange resin(s).

In an embodiment, the present disclosure relates to a method of ameliorating or preventing a disease or disease condition. Generally, the method includes administering a composition having a synthetic lysine analog, derivative, or mimetic. In some embodiments, the synthetic lysine analog, derivative, or mimetic interacts with cells associated with the disease or disease condition to inhibit or prevent replication, survival, or formation of the cells. In another embodiment, the present disclosure relates to a composition having a synthetic lysine analog, derivative, or mimetic for ameliorating or preventing a disease or disease condition. In a further embodiment, the present disclosure is related to a method and composition having a synthetic lysine analog, derivative, or mimetic for ameliorating aging. In an additional embodiment, the present disclosure is related to a method and composition having a synthetic lysine analog, derivative, or mimetic for treatment and prevention of cancer.

In an embodiment, the present disclosure relates to a method of ameliorating or preventing a disease or disease condition. Generally, the method includes administering a composition having a synthetic lysine analog, derivative, or mimetic. In some embodiments, the synthetic lysine analog, derivative, or mimetic interacts with cells associated with the disease or disease condition to inhibit or prevent replication, survival, or formation of the cells. In another embodiment, the present disclosure relates to a composition having a synthetic lysine analog, derivative, or mimetic for ameliorating or preventing a disease or disease condition. In a further embodiment, the present disclosure is related to a method and composition having a synthetic lysine analog, derivative, or mimetic for ameliorating aging. In an additional embodiment, the present disclosure is related to a method and composition having a synthetic lysine analog, derivative, or mimetic for treatment and prevention of cancer.

This invention relates to the finding that Piperlongumine compounds, such as Piperlongumine and analogues, derivatives and prodrugs thereof, are reversible, allosteric antagonists of transient receptor potential vanilloid 2 channel (TRPV2). Methods of treatment of conditions that are characterised by TRPV2 expression using Piperlongumine compounds and Piperlongumine compounds for use in such treatments are provided.

The present invention provides pharmaceutical compositions and methods of use of bisbenzylisoquinoline, e.g., 6,6',7,12-tetramethoxy-2,2'-dimethyl-berbaman, and analogs, derivatives, isomers, and modified forms of the compound, e.g., in crystalline, salt, or salt form, in combination with pharmaceutically acceptable acids or other agents, for the treatment of acute, chronic, and preleukemic conditions, as well as lymphoma and solid tumors. These include, but are not limited to, preneoplastic and neoplastic diseases and solid tumors, such as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), atypical chronic myeloid leukemia (aCML), and acute myeloid leukemia (AML), polycythemia vera (PV), chronic lymphoblastic leukemia (CLL), myeloproliferative syndrome (MPS), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), myelofibrosis (MF), and polycythemia vera (PV).

This invention discloses compositions containing sesamol compounds and their applications. The compositions include at least two of sesamol, sesamol dimer, and sesamin glucoside. This invention uses specific compounds from sesamol and its analogues, derivatives, and metabolites as the main active ingredients, resulting in compositions that exhibit synergistic effects, significantly enhancing physiological activities such as controlling body fat, regulating intestinal flora, maintaining blood lipids / blood sugar / blood pressure, protecting the liver, controlling appetite, anti-oxidation, and anti-aging. Furthermore, all components in this composition are derived from pure natural plant-based foods, with no toxic side effects; and the preparation method is simple and easy to operate, making it suitable for preparing related health foods, pharmaceuticals, feed, and feed additives, with promising application prospects.

The invention discloses preparation and application of a polyphenol amine coating with multienzyme activity. Catechol and analogues / derivatives thereof and polyamine compounds with economic benefits are used as raw material monomers to simulate the auto-polymerization process of dopamine, so that the dopamine is loaded on a proper substrate; in the process, active oxygen generated by Fenton or Fenton-like reaction of metal ions and hydrogen peroxide is used for accelerating the auto-polymerization of the polyphenol amine coating, the time cost is greatly saved, and the metal ions are coordinated with phenolic groups, amino groups, o-quinone and other structures in the polyphenol amine structure, so that the polyphenol amine coating is endowed with enzyme-like activity. The polyphenol amine structure disclosed by the invention can form a polymer coating on the surfaces of various substrates, and can be widely applied to detection of related substances in foods, medicines and environments and removal of pollutants.

The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to mustard-based alkylating agents such as uracil mustard and analogs, derivatives, or prodrugs thereof, including 6-methyluracil mustard and 6-ethyluracil mustard.

To provide a method for treating hot flash in a subject.SOLUTION: A method has administering a therapeutically effective amount of a transient receptor potential channel (TRP channel) blocker or pharmaceutically acceptable salt thereof. Preferably, the TRP channel blocker is a TRP channel subfamily V member 1 (TRPV1) blocker, or a pharmaceutical equivalent, analog, derivative, or salt thereof.SELECTED DRAWING: None

The invention discloses a composition containing sesamol compounds and application of the composition. The composition comprises at least two of sesamol, a sesamol dimer and sesamol glucoside. Specific compounds in sesamol and analogues, derivatives and metabolites of sesamol are combined and matched and are used as main active ingredients, so that the obtained composition can generate a synergistic effect; the physiological activity in the aspects of controlling body fat, regulating intestinal flora, maintaining blood fat / blood sugar / blood pressure, protecting liver, controlling appetite, resisting oxidation, resisting aging and the like is obviously improved. Meanwhile, the components in the composition are all from pure natural plant food and have no toxic or side effect; and the preparation method is simple and easy to operate, can be used for preparing related foods, medicines, feeds and feed additives, and has a good application prospect.

The invention discloses an application of fisotinib or a pharmaceutically acceptable salt thereof in preparation of an antiviral drug. In-vitro drug experiments and in-vivo drug experiments of the invention find that the fesotinib or pharmaceutically acceptable salts, solvates, hydrates, prodrugs, isomers, analogues, derivatives or metabolites of the fesotinib can significantly inhibit the replication of various viruses, and especially show potent antiviral activity in certain virus infection models.

A method for treating cancer comprises the combined use of a therapeutically effective amount of elzovtinib or an elzovtinib analog, a derivative thereof, or a pharmaceutically acceptable salt, and a therapeutically effective amount of bortezomib, ibrutinib, or an analog, derivative, or pharmaceutically acceptable salt thereof. The composition and kit are included herein. The cancer may be refractory to bortezomib and / or ibrutinib.