38 results about "Analogues/Derivatives" patented technology

The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

This invention provides methods and compositions for inhibiting, reducing or slowing inflammatory diseases, for reducing sequestration or collecting or localization of macrophages, for treating a disease caused all or in part by or characterized by inflammation, for inhibiting, slowing, reversing or preventing atherosclerosis, and for increasing insulin sensitivity, decreasing or inhibiting resistance to insulin, or treating diabetes by inhibiting the biological activity of or antagonizing an axonal guidance protein. The method may feature administering a therapeutically effective amount of an agent to reduce or inhibit the biological activity of an axonal guidance protein or a receptor, analog, derivative or combination thereof.

The invention provides polypeptides with the function of self-assembled potassium channel. The main sequence of polypeptides fragmentations, analog, derivative and variant amino acid of polypeptide possesses great than or equal to 70% of homology and great than or equal to 90% of similarity compared with the main sequence of the polypeptides amino acid. Polypeptides, nucleotide, polypeptide fragmentations, polypeptide analog, polypeptide derivatives and polypeptides variant are used for preparing the medicines which can treat diseases caused by potassium channel functional disorder / deficiency and hypertension, and also used for preparing tool drugs in the research field which can modify liposome and cell membrane potential. The invention provides a novel method for treating diseases caused by potassium channel functional disorder / deficiency and modifying cell membrane potential.

Compounds, methods, uses, compositions, kits and packages for the prevention and / or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and / or analogs, derivatives, pro-drugs, precursors thereof, and / or salts thereof, are described.