A method of high-shear wet
granulation, HWSG,
processing, the method comprising: providing a set of
powder substances (Pi, Po) in a HSWG
processing space (12) The HSWG
processing space (12) comprises at least one mixing device (14, 16). The method further comprises: exerting at least one torque via at least one motor (MA, MC) coupled to the at least one mixing device (14, 16); sensing (S; S0, S1, S4) a first sensing
signal (I, ω) indicative of said torque (T) exerted by the motor (MA, MC) of the at least one mixing device (14, 16) to blend the powders (Pi, Po) having a dry
mass; providing at least one adjustable flow (VV) of at least one liquid substance (L1, L2) in the HSWG processing space (12) via a liquid distribution device (L) and
wetting the first
powder substance (Pi) therewith; sensing (S, S3) a second sensing
signal indicative of the liquid flow introduced in the processing space (12) via the liquid distribution device (L); based on the second sensing
signal, computing a cumulative amount of liquid introduced in the HSWG processing space (12) and normalizing the computed value by the dry
mass, obtaining a liquid- to-
solid ratio as a result; adjusting (306) the flow of the at least one liquid substance (L1, L2) based on the
computed torque and liquid-to-
solid ratio. The method also comprises detecting a second HSWG process
transition point, e.g., by computing a third derivative of the
computed torque with respect to the computed liquid-to-
solid ratio and detecting a zero-crossing therein, and introducing a pre-set amount of at least one second
powder substance (Po) in the HSWG processing space (12) and mixing the blended powder with the at least one second powder material (Po).