53 results about "Reagent testing" patented technology

Reagent test strips and methods for their use in the determination of the concentration of an analyte, e.g. glucose, in a physiological sample, are provided. The subject reagent test strips include one or more members of an analyte oxidation signal producing system and at least one hemolyzing agent. The subject reagent test strips and methods are particularly suited for use in the detection of blood glucose concentrations. Also provided are kits that include the subject test strips for use in practicing the subject methods.

A portable system for real time detection of the presence of an infectious agent in a biological sample employs a reagent which detects the presence of a specific infectious agent in the sample, and emits a detectable signal when the reagent reacts with the sample and detects the presence of the infectious agent. A test cartridge has a reaction chamber for receiving the sample and the reagent. The reaction chamber has a predetermined internal geometry and at least one inner surface. Introducing the sample and the reagent into the test cartridge mixes the sample and the reagent. A testing unit receives the test cartridge, and includes a sensor for detecting an emitted detectable signal. The detection of the emitted detectable signal is indicative of the presence of the infectious agent in the sample.

Systems and methods for testing visible chemical reactions of a reagent are provided. In one implementation, the method may include receiving from an image sensor associated with a mobile communications device an image of a reagent with a plurality of colored test reagent pads in proximity to a colorized surface having a plurality of colored reference elements of differing shades. The method further includes using the differing shades of the plurality of colored reference elements to determine local illumination conditions. Thereafter, the method includes using the determined local illumination conditions and an analysis of a depiction of the plurality of colored test reagent pads in the image to determine an extent of a chemical reaction on the reagent. Then the method includes causing the mobile communications device to provide to the user an indication that the testing of the reagent is complete.

The invention provides an electrode for determining nitrate concentration in a solution, a manufacturing method thereof and a method for determining the nitrate concentration in the solution by using the electrode. The electrode comprises a titanium wire and a glass tube sleeved on the titanium wire, wherein one end of the glass tube contracts to tightly wrap the outer wall of one end of the titanium wire; only the end face of the titanium wire is exposed out of the glass tube; and particular nano copper is deposited in the naked end face of the titanium wire. The concentration of nitrate in the solution can be obtained by putting the electrode into a nitrate-containing solution to be determined according to x in a formula, i.e., y=a+bx, wherein y is a logarithmic value of more than ten of the concentration of nitrate, x is a logarithmic value of more than ten of electrode current, and a and b are linear coefficients. The electrode has high selectivity on nitrate in a neutral solution, no reagent is required to be added additionally during testing, the testing process is quick, simple and convenient, and a large scale of samples can be tested. Meanwhile, the manufacturing method is simple and quick, and has low cost.

This invention provides a device for determining the concentration of an analyte like glucose, cholesterol, free fatty acids, triglycerides, proteins, ketones, phenylalanine or enzymes, in a physiological or aqueous fluid like blood, serum, plasma, saliva, urine, interstitial and / or intra-cellular fluid, the device having an integrated calibration and quality control system suitable for dry reagent test strips with a very small sample volume of about 0.5 μL based on to a new sample distribution system. The production of the inventive analyte test element involves only a small number of uncomplicated production steps enabling an inexpensive production of the strips.

A system for laying down stripes of solution on substrate is described. The substrate preferably comprises a web of material set on a backing roller passed by a specially configured die. The die includes at least a mouth with lips extending beyond a face or body of the die. The die is adapted to avoid fluid leakage therefrom. Upper and lower portions of the die defining the mouth are preferably substantially flat and mirror images of each other. The lips are preferably placed in close proximity to the material on which the solution is to be deposited. Solution passing through the mouth of the die is directed to the webbing and deposited in a substantially constant thickness stripe or band. Often, the solution comprises a reagent-type solution. The solution coating is typically dried onto the substrate. Dried product may then be used in reagent test strop production.

The invention relates to a novel reagent testing card of clenobuterol hydrochloride. The novel reagent testing card of clenobuterol hydrochloride comprises a reagent strip and a housing with a containing space, wherein the reagent strip is accepted in the housing. The reagent strip includes a protective film, a baseboard, and includes a sample absorbing pad, a colloidal gold pad, a nitrocellulose membrane, and a water absorbing pad, which are connected in sequence and arranged on the baseboard. The protective film is arranged on one side of the nitrocellulose membrane. The colloidal gold pad coats a clenobuterol hydrochloride antibody. The nitrocellulose membrane is provided with a test line and a quality control line, wherein the test line coats a clenobuterol hydrochloride protein conjugate and is arranged near the colloidal gold pad. The quality control pad coats sheep or rabbit anti-mouse antibody and is near the water absorbing pad. The novel reagent testing card of clenobuterol hydrochloride effectively prevents air environmental factors against affecting color development of the test line, and has advantages of good test effect and quantitative test application.

The invention discloses an inspection and test method for a modified polypropylene plastic cable protection pipe. The inspection and test method comprises the following steps: 1) preparing inspectionpretreatment; 2) sampling the reasonable position of a modified polypropylene cable protection pipe; 3) testing an inspection reagent; 4) carrying out Vicat softening performance test; 5) judging an inspection result: judging that a test part is qualified when an upper limit solution of detection reagent samples is suspended and a lower limit solution of the samples is settled, otherwise, judgingthat the test part is unqualified; if the Vicat softening test temperature is more than 150 DEG C, judging that the sample is qualified, otherwise, judging that the sample is unqualified; and judgingthat the whole section of the inspection pipe is unqualified if unqualified samples appear. By means of the field density testing method, the mass density characteristics of related samples of the cable protection pipe can be accurately tested and evaluated, pre-detection is achieved, and the quality safety rate and the parameter qualification rate of products are increased.

Systems and methods for testing visible chemical reactions of a reagent are provided. In one implementation, the method may include receiving from an image sensor associated with a mobile communications device an image of a reagent with a plurality of colored test reagent pads in proximity to a colorized surface having a plurality of colored reference elements of differing shades. The method further includes using the differing shades of the plurality of colored reference elements to determine local illumination conditions. Thereafter, the method includes using the determined local illumination conditions and an analysis of a depiction of the plurality of colored test reagent pads in the image to determine an extent of a chemical reaction on the reagent. Then the method includes causing the mobile communications device to provide to the user an indication that the testing of the reagent is complete.

The invention discloses an analyzer sample apparatus. The analyzer sample apparatus comprises a reagent container and a syringe; and is characterized in comprising a sensor, a liquid storage chamber, a first magnetic valve, and a second magnetic valve which are arranged between the reagent container and the syringe, and are connected end to end via a pipeline successively. The head end of the liquid storage chamber and the first magnetic valve are connected via another pipeline. The invention also provides a reagent testing method of the analyzer sample apparatus. According to the reagent testing method, when it is detected by the sensor that no reagent is in the analyzer sample apparatus, a control circuit is used for reminding that no reagent is in the analyzer sample apparatus; and when the amount of the reagent in the liquid storage chamber is enough for one time of sample count, then the control circuit will allow this time of sample count to be performed continuously. The analyzer sample apparatus and the reagent testing method possesses following advantages: cost is relatively low, detection is reliable, the control circuit is sample, and operation is convenient.

A reagent test paddle includes a contamination detection medium, a reference color bar, at least one chemical test medium, and a unique identifier. The contamination detection medium includes a reagent that changes color in the presence or when exposed to a hostile or inhospitable environment. Each chemical test medium includes a regent that is responsive to a respective analyte in a biological sample. The reference color bar includes reference color samples of different colors. The unique identifier, like a serial number, identifies the particular paddle and its chemical test medium so it can be uniquely and anonymously associated with a user. A method includes capturing and interpreting digital images of a biologically unexposed and subsequently exposed reagent test paddle at various delay times within an automatically calibrated environment; locating the paddle in a plurality of digital images, extracting the reference color bar and locating the contamination detection medium and chemical test medium in each digital image. Color changes of the chemical test medium and contamination medium are detected at various delay times after sample exposure. To determine validity of test results, the method further compares the detected colors of the contamination detection medium with predetermined colors expected for no contamination and contamination.

The invention discloses a fluorescence immunoassay and colloidal gold method reagent automatic judgment method, which comprises the following steps: firstly, acquiring a reagent image or graph after reaction by adopting a camera or laser excitation, and then carrying out filtering, morphological analysis, base value removal and wave crest detection treatment on the acquired image or graph; the ratio of the quality control line peak area C to the test line peak area T is calculated and compared with a threshold value to determine the strength of a reagent test result, so that automatic judgment of the reagent is realized; the method solves the problems of manual discrimination errors, low efficiency, easy fatigue and the like of reagent reaction results, realizes automatic determination of fluorescence immunoassay and colloidal gold method reagents, rapidly and accurately identifies the results after reagent reaction, is more accurate and stable, can be applied to colloidal gold method series reagents and fluorescence immunoassay series reagents, and has wide application prospects. The method can be used for automatically judging the reaction results of similar reagent products, and can also be used for automatically judging other similar reagents tested by a quality control line and a test line.

The invention relates to clamping equipment, in particular to multi-quantity automatic clamping equipment for producing reagent test boxes. The technical problem to be solved by the invention is to provide the multi-quantity automatic clamping equipment for producing the reagent test box, which can prevent reagent cards from being damaged during packaging and can improve the boxing efficiency. In order to solve the technical problem, the invention provides the multi-quantity automatic clamping equipment for producing the reagent test box, which comprises supporting legs, a first supporting plate, a second supporting plate, a baffle plate, a rotating plate and the like, the number of the supporting legs is two, the two supporting legs are bilaterally symmetrical, the tops of the supporting legs on the two sides are both connected with first supporting plates, the first supporting plate on the left side is used for placing a reagent test card, and the first supporting plate on the right side is used for placing a top cover of a reagent test box. When the equipment is used, the rodless cylinder is started to drive the sliding frame to move, and the reagent test card and the top cover can be assembled on the bottom box through cooperation of the swing blocks on the front side and the rear side and the guide rail assembly, and manual assembly by people is not needed.

The invention discloses a bacterial colony chromogenic medium capable of achieving autoclaved sterilization and the preparing method and application thereof. Each liter of the medium contains 23.5 g market plate count agar, 0.005-0.015 g sucrose fatty acid ester SE-11 and 0.005-0.015 g 2,3,5-triphenyltetrazolium chloride. The medium can be used for measuring the number of bacterial colonies in food and food additives, bacterial colonies are red or light red, boundaries are clear, bacterial colony color development is obvious, counting is easy, and the medium can be popularized to actual testing to facilitate reagent testing.

This disclosure relates to a screening test method, device, and kit for carbohydrates found in a biological sample and associated conditions including, cancerous and precancerous conditions. Specifically, the method tests abnormal carbohydrates in a biological sample using reagents of galactose oxidase, and Schiff's Reagent. The screening test method, device, and kit provides expanded testing capabilities across a range of known conditions and in an otherwise healthy population. This disclosure further relates to the use of the device or kit for an initial evaluation for cancerous and precancerous conditions in people without obvious signs and symptoms, and cancer recurrence in at point-of-care facility or at home.

A system for depositing strips on a substrate. The substrate preferably consists of a strip of material mounted on support rollers and passed through a specially constructed mold. The mold includes at least one mouth having a lip extending beyond the body or surface of the mold. The mold prevents fluid leakage. Preferably, the upper and lower body portions of the mold in which the mouth is formed are substantially flat and mirror-image opposed to each other. The lip is preferably located close to the substrate strip where the solution is deposited. The solution passes through the mouth of the mold to the belt and settles on the belt in the form of a ribbon of essentially constant thickness. The solution is usually a reagent solution. The solution coating is typically dried on the substrate. The dried product can be used in the production of reagent test strips.

A method for synthesizing and screening a lead compound, comprising the following steps: (1) retrieving raw materials: retrieving an i-number of synthetic blocks and an (i+2)-number of single-stranded DNA fragments; (2) synthesizing a compound by using a combinatorial chemistry method, acquiring a library of a single-stranded DNA-marked compound; (3) screening: screening the library of the DNA-marked compound; and, (4) sequencing: retrieving the DNA-marked compound screened in step (3), and sequencing the DNA on the DNA-marked compound, where the synthesis blocks and reaction mechanism of the compound can be determined on the basis of the DNA sequencing. Also disclosed are a synthesis and screening reagent testing kit for the lead compound and a combinatorial chemistry library.

Provided are a reagent test kit and use thereof in sequencing. The reagent test kit includes a first reagent and a second reagent. The first reagent is selected from a disulfide bond reducing agent. The second reagent is selected from a blocking reagent suited to blocking a disulfide bond.

A computer-implemented method for determining a numerical analyte result value corresponding to the concentration of an analyte in a sample of a subject's body fluid applied to a reagent test area includes: (a) determining the numerical analyte result value based on an image of the reagent test area by using an algorithm that takes into account one or more parameters, each parameter adapted to take two or more values; (b) displaying the numerical analyte result value, and / or the corresponding analyte value range, and / or a corresponding message on a display device; and (c) automatically checking for available updated values ​​for one or more parameters on a remote server before performing step (a), and updating the corresponding parameter value taken into account in step (a) for each available updated value.

A method using a chemical analyzer for removing a component of a liquid sample which may interfere with a test performed on a test assay includes the steps of adding the liquid sample to a sample cup, transferring a volume of the liquid sample to a mixing cup containing an IMAC (Immobilized Metal Affinity Chromatography) resin containing porous beads to form a sample / resin solution in the mixing cup, using a pipette of the chemical analyzer to repeatedly aspirate the sample / resin solution into a disposable pipette tip of the pipette and expelling the sample / resin solution from the pipette tip into the mixing cup to achieve a mixed sample / resin solution in the mixing cup, and allowing the mixed sample / resin solution in the mixing cup to rest undisturbed so that the interfering component of the liquid sample adheres to the porous beads and the beads settle to a bottom portion of the mixing cup, resulting in a refined liquid sample devoid of the interfering component and occupying an upper portion of the mixing cup for later dispensing on the test assay.

A prefabricated multi-test kit, the kit that comprises a plurality of reaction cells, each one of at least two of the reaction cells holding reagents of a respective, different set of at least two tests selected from a group consisting of a plurality of different tests, the tests being distributed among the reaction cells in a manner that leaves reagents of each different one of the tests of the group in a respective different sub-combination of the reaction cells, and allows any sub-combination of the reaction cells to be indicative of a sub-group comprising all positive tests of the group when each reaction cell of the sub-combination that is indicative of the sub-group, contains an at least one positive test and none of the remaining reaction cells contain a positive test.

The invention provides a fluorescent quantitative detection reagent for cat cystatin C and a preparation method thereof, and relates to the field of biological detection. The fluorescent quantitative detection reagent for the cat cystatin C comprises the following raw materials: a treating fluid, a glass fiber membrane, an MES buffer solution, microspheres, EDC-HCl, NHS, a sealing agent and a marking diluent. The preparation method comprises the following steps: S1, (1) preparing the following solutions by using 10 mM of PBS: 3% of BSA, 3% of sucrose, 1% of PVP-K30, 1% of casein, 1% of PEG20000, 0.1% of Triton X-100 and 0.02% of NaN3; and (2) at room temperature, soaking a glass fiber membrane with the treating fluid for 12 hours; S2, diluting 0.25 mL of 1 [mu]mol / L microspheres with 0.25 ml of 20 mmol / L MES buffer solution to a concentration of 0.5 [mu]mol / L; S3, adding 5 [mu]l of EDC-HCl with a concentration of 20 mg / ml and 5 [mu]l of NHS with a concentration of 20 mg / ml into the MES buffer solution; S4, after activating the microspheres, immediately adding 0.1 mg of to-be-labeled antibody; S5, adding 25 [mu]l of a sealing agent, and re-suspending and dispersing by using 2 ml of a marking diluent; and S6, spraying a combination pad. According to the invention, by improving the sensitivity of reagent testing and prolonging the validity period of the reagent, industrial production is facilitated.

The utility model provides a handheld reagent card analyzer, which belongs to the technical field of reagent detection equipment and comprises a shell and a limiting elastic sheet, a clamping groove for inserting the reagent card is formed in the side face of the shell, the limiting elastic piece is installed in the shell and located on one side of the clamping groove, and one end of the limiting elastic piece extends into the clamping groove and abuts against the side face of the reagent card. According to the handheld reagent card analyzer provided by the utility model, the limiting elastic sheet is mounted on one side of the clamping groove, and one end of the limiting elastic sheet extends into the clamping groove, so that after the reagent card is inserted into the clamping groove, the limiting elastic sheet applies an acting force to the side surface of the reagent card by virtue of the elasticity of the limiting elastic sheet, and the reagent card is relatively fixed in the clamping groove; therefore, the reagent card is prevented from shaking, and the accuracy of a detection result is ensured.

A system for depositing strips on a substrate. The substrate preferably consists of a strip of material mounted on support rollers and passed through a specially constructed mold. The mold includes at least one mouth having a lip extending beyond the body or surface of the mold. The mold prevents fluid leakage. Preferably, the upper and lower body portions of the mold in which the mouth is formed are substantially flat and mirror-image opposed to each other. The lip is preferably located close to the substrate strip where the solution is deposited. The solution passes through the mouth of the mold to the belt and settles on the belt in the form of a ribbon of essentially constant thickness. The solution is usually a reagent solution. The solution coating is typically dried on the substrate. The dried product can be used in the production of reagent test strips.

The present invention relates to a computer-implemented analytical measurement method for detecting a first analyte and a second analyte in a single sample of a bodily fluid, - wherein the first analyte is detectable from a first reagent test region (25) of a hybrid test element (40), the first reagent test region being configured for performing an optical detection reaction in the presence of the first analyte; - wherein the second analyte is detectable from a second reagent test region (26) of the hybrid test element, the second reagent test region being configured for performing an electrochemical detection reaction in the presence of the second analyte; and - wherein the first analyte is detectable from the first reagent test region, by using a camera (64) of a mobile device (60), when the hybrid test element is connected to an electrochemical reader unit (70); the method comprising: i) receiving an image captured by the camera of the mobile device, the image comprising a part of the first reagent test region having a first part of the single sample of the bodily fluid applied thereto; the image being captured when the hybrid test element is connected to an electrochemical reader unit; and ii) detecting the first analyte by using the image received in step i); and iii) detecting the second analyte by iii.a) using the image received in step i), the image further comprising a part of the electrochemical reader unit having an optically detectable indicator element (78) which is indicative of the electrochemical detection reaction; or iii.b) using a wireless signal received from the electrochemical reader unit (transmission unit 82), the wireless signal being indicative of the electrochemical detection reaction; wherein the second reagent test region has a second part of the single sample of the bodily fluid applied thereto.

The present application relates to the technical field of clinical in vitro detection reagent, especially relates to reagent combination and its application in eliminating MALB reagent non-specific interference detection. When MALB reagent is calibrated at 0 point with purified water, and normal human urine sample is tested on a biochemical instrument, the test value can be 0 or negative, especially when the concentration of urine is 0 mg / L-5 mg / L, the test value is basically 0. The present application selects suitable Malb antibody and suitable antibody feeding amount to improve the sensitivity of reagent, and selects suitable background solution in the reaction system to reduce the non-specific interference of MALB reagent. Not only the problem of 0 or negative sample value is effectively improved, but also the detection accuracy is improved, which has important significance for improving the accuracy of MALB reagent test sample. The reagent combination provided by the present application has good clinical application and large-scale industrial production prospect.

The utility model discloses a biological reagent inspection dissolving and filtering device, and particularly relates to the technical field of biological reagent inspection, the biological reagent inspection dissolving and filtering device comprises a vertical cylinder and a material storage cylinder, the material storage cylinder is in threaded connection with the edge of the bottom of the outer side of the vertical cylinder, a filter screen plate is movably arranged in the vertical cylinder, and a rotating assembly is arranged at the top of the filter screen plate; the rotating assembly comprises a hydraulic cylinder, a mounting plate, a motor, a rotating shaft, three stirring rods and a bristle plate, the bottom end of the hydraulic cylinder is fixedly connected with the mounting plate, and the motor is fixedly mounted at the bottom end of the mounting plate. The motor works to drive the three stirring rods to rotate, the three stirring rods stir biological reagents and diluents, the filter screen plate filters mixed liquid, meanwhile, the rotating shaft can drive the bristle plate to rotate, bristles on the bristle plate clean blocky objects attached to the filter screen plate, operation is easy, and the operation is convenient. Blocky objects adhered to the filter screen plate can be conveniently cleaned, the filtering efficiency is effectively improved, and the use effect is good.

The utility model discloses a chemical reagent testing device and belongs to the technical field of testing devices. A chemical reagent testing device comprises a box body with a box door, and further comprises an upper chamber and a lower chamber which are both formed in the box body, a partition plate is arranged between the upper chamber and the lower chamber in a sliding mode, and a plurality of first through holes are formed in the partition plate; the breathable plate is arranged at the top of the upper cavity in a sliding mode, a plurality of second through holes are formed in the breathable plate, and a containing part used for installing workpieces is arranged in the upper cavity; the whole box body is placed in the incubator, gasified chemical reagents enter the upper cavity through the first through hole and then flow out of the second through hole, in the whole test process, products can be corroded by chemical reagent gas all the time, condensation cannot be generated, the products are closer to the state that the products on a real vehicle are corroded after being stained with the chemical reagents, and the product quality is improved. And the chemical reagent corrosion stress resistance of the product can be conveniently verified.