The invention discloses a method for processing signals of pico-satellite transmitters, which includes the following steps: digital baseband signals are converted into analog signals, image signals in the analog signals are then extracted, filtered and amplified, so that processed image signals are obtained, the processed image signals are mixed with radio frequency local oscillation, so that mixed signals are obtained, and finally, the mixed signals are filtered and amplified, so that radio frequency signals are obtained. The invention also discloses a device for processing signals of pico-satellite transmitters. The invention adopts a primary up-conversion structure to replace the secondary up-conversion structure of the conventional transmitter, dispensing with a first-stage medium-frequency local oscillator and a first-stage mixer on the link, consequently, the area of the circuit is reduced, the power consumption and complexity of the circuit are decreased, the primary spectrum shifting process is reduced, and under the premise of guaranteeing the good output characteristics of a digital-to-analog converter, the invention can effectively enhance the performance and stability of the whole transmission link.