The invention discloses a natural image denoising method based on the regional division, which mainly solves the problem that patches exist in an image after an image is donoised through the existing three-dimensional block matching denoising algorithm. The method comprises the following steps: firstly, performing two-dimensional stationary wavelet transform on an input image to be denoised, and performing inverse transform on a high frequency coefficient subjected to zero setting, so as to obtain a reconstructed image; secondly, exacting the structural information of the reconstructed image, so as to obtain an image structure sketch; thirdly, dividing the noisy original image into a structure region, a smooth region and a non-smooth region through statistic features of an image block and the image structure sketch; fourthly, performing denoising on the smooth region with an improved non-local mean method, performing denoising on the non-smooth region with a BM3D (Block matching 3D) method, and performing denoising on the structure region with a directional feature-based BM3D method; and fifthly, combining estimated results of the structure region, the smooth region and the non-smooth region, so as to obtain the final denoised image. The method can be used for preprocessing natural images.